Avocado Oil Extract Modulates Auditory Hair Cell Function Through the Regulation of Amino Acid Biosynthesis Genes

Overview

Journal Nutrients

Date 2019 Jan 11

PMID 30626089

Citations 4

Authors

Youn Hee Nam

Isabel Rodriguez

Seo Yeon Jeong

Thu Nguyen Minh Pham

Wanlapa Nuankaew

Yun Hee Kim

Rodrigo Castaneda

Seo Yule Jeong

Min Seon Park

Kye Wan Lee

Jung Suk Lee

Do Hoon Kim

Yu Hwa Park

Seung Hyun Kim

In Seok Moon

Se-Young Choung

Bin Na Hong

Kwang Won Jeong

Tong Ho Kang

Affiliations

Soon will be listed here.

Abstract

Sensorineural hearing loss (SNHL) is one of the most common causes of disability, affecting over 466 million people worldwide. However, prevention or therapy of SNHL has not been widely studied. Avocado oil has shown many health benefits but it has not yet been studied in regards to SNHL. Therefore, we aimed to investigate the efficacy of avocado oil on SNHL in vitro and in vivo and elucidate its mode of action. For the present study, we used enhanced functional avocado oil extract (DKB122). DKB122 led to recovery of otic hair cells in zebrafish after neomycin-induced otic cell damage. Also, DKB122 improved auditory sensory transmission function in a mouse model of noise induced-hearing loss and protected sensory hair cells in the cochlea. In addition, RNA sequencing was performed to elucidate the mechanism involved. KEGG pathway enrichment analysis of differentially expressed genes showed that DKB122 protected House Ear Institute-Organ of Corti 1 (HEI-OC1) cells against neomycin-related alterations in gene expression due to oxidative stress, cytokine production and protein synthesis.

Citing Articles

Anti-Aging Potential of Avocado Oil via Its Antioxidant Effects.

Torres-Isidro O, Gonzalez-Montoya M, Vargas-Vargas M, Florian-Rodriguez U, Garcia-Berumen C, Montoya-Perez R Pharmaceuticals (Basel). 2025; 18(2).

PMID: 40006059 PMC: 11858862. DOI: 10.3390/ph18020246.

Effects of on Sensorineural Hearing Loss via Neuronal Gene Regulation.

Rodriguez I, Nam Y, Shin S, Seo G, Kim N, Nuankaew W Nutrients. 2024; 16(16).

PMID: 39203853 PMC: 11357119. DOI: 10.3390/nu16162716.

Amelioration of Sensorineural Hearing Loss through Regulation of , , and Gene Expression by a Combination of Cuscutae Semen and Rehmanniae Radix Preparata.

Hong B, Shin S, Nam Y, Shim J, Kim N, Kim M Nutrients. 2023; 15(7).

PMID: 37049613 PMC: 10097224. DOI: 10.3390/nu15071773.

Fatty Acid Derivatives Isolated from the Oil of (Avocado) Protects against Neomycin-Induced Hair Cell Damage.

Park S, Jeong S, Nam Y, Park J, Rodriguez I, Shim J Plants (Basel). 2021; 10(1).

PMID: 33477487 PMC: 7831075. DOI: 10.3390/plants10010171.

Protective Mechanisms of Avocado Oil Extract Against Ototoxicity.

Pham T, Jeong S, Kim D, Park Y, Lee J, Lee K Nutrients. 2020; 12(4).

PMID: 32235401 PMC: 7230542. DOI: 10.3390/nu12040947.

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