Effects of Dodecacalcium Hepta-aluminate Content on the Setting Time, Compressive Strength, Alkalinity, and Cytocompatibility of Tricalcium Silicate Cement

Overview

Journal J Appl Oral Sci

Specialty Dentistry

Date 2019 Jan 10

PMID 30624470

Citations 2

Authors

Yoorina Choi

Jong-Lye Bae

Hee-Jin Kim

Mi-Kyung Yu

Kwang-Won Lee

Kyung-San Min

Affiliations

Soon will be listed here.

Abstract

Objective: This study aimed to investigate the effects of dodecacalcium hepta-aluminate (C12A7) content on some physicochemical properties and cytocompatibility of tricalcium silicate (C3S) cement using human dental pulp cells (hDPCs).

Material And Methods: High purity C3S cement was manufactured by a solid phase method. C12A7 was mixed with the cement in proportions of 0, 5, 8, and 10 wt% (C12A7-0, -5, -8, and -10, respectively). Physicochemical properties including initial setting time, compressive strength, and alkalinity were evaluated. Cytocompatibility was assessed with cell viability tests and cell number counts. Statistical analysis was performed by using one-way analysis of variance (ANOVA) and Tukey's test (p<0.05).

Results: The initial setting time of C3S-based cement was shorter in the presence of C12A7 (p<0.05). After 1 day, C12A7-5 showed significantly higher compressive strength than the other groups (p<0.05). After 7 days, the compressive strength of C12A7-5 was similar to that of C12A7-0, whereas other groups showed strength lower than C12A7-0. The pH values of all tested groups showed no significant differences after 1 day (p>0.05). The C12A7-5 group showed similar cell viability to the C12A7-0 group (p>0.05), while the other experimental groups showed lower values compared to C12A7-0 group (p<0.05). The number of cells grown on the C12A7-5 specimen was higher than that on C12A7-8 and -10 (p<0.05).

Conclusions: The addition of C12A7 to C3S cement at a proportion of 5% resulted in rapid initial setting time and higher compressive strength with no adverse effects on cytocompatibility.

Citing Articles

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Rao A, Venkatesh K, Nandini V, Sihivahanan D, Alamoudi A, Bahammam H Materials (Basel). 2022; 15(13).

PMID: 35806692 PMC: 9267687. DOI: 10.3390/ma15134567.

Bioactive tri/dicalcium silicate cements for treatment of pulpal and periapical tissues.

Primus C, Tay F, Niu L Acta Biomater. 2019; 96:35-54.

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