Study of Prevalence of Dermatophytes Among Human Immunodeficiency Virus/AIDS Patients in Shadan Institute of Medical Sciences and Teaching Hospital and Research Centre, Hyderabad, Telangana, India

Overview

Journal Indian J Sex Transm Dis AIDS

Specialty Infectious Diseases

Date 2019 Jan 10

PMID 30623179

Citations 1

Authors

Syed Yousuf Ali

Sukumar Reddy Gajjala

Akhilesh Raj

Affiliations

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Abstract

Introduction: The objective of the study was to evaluate the prevalence of dermatophytoses in human immunodeficiency virus (HIV) patients as well as to analyze the influence of CD4+ T-cell level in the Dermatology and STD Outpatient Department of Shadan Institute of Medical Sciences Teaching Hospital and Research Centre, Himayat sagar road, Hyderabad (Telangana state). The patients were tested for dermatophytic infections, as well as for the CD4+ T-cell counts. A total of 120 HIV-seropositive patients were included in this study, among which 38 were diagnosed of dermatophytosis. A majority of patients were in the 21-30 years' age group. Tinea cruris was seen in majority of the cases, with being the most common culprit.

Background: Cutaneous fungal infections have been reported worldwide as being one of the most common human infectious diseases in clinical practice. Dermatophytoses in individuals with HIV infection seem to manifest with atypical, multiple, or extensive lesions more frequently.

Aims: The aim of this study was to determine the prevalence of dermatophytic infections among HIV-seropositive patients and their relation with CD4 count.

Materials And Methods: This single-center prospective study was conducted in all HIV-seropositive patients (by double ELISA methods) who attended the Dermatology and STD Outpatient Department of Shadan Institute of Medical Sciences Teaching Hospital and Research Centre, Himayat sagar road, Hyderabad (Telangana state), from March 2015 to September 2016. They were screened for cutaneous fungal infections and those who tested positive were recruited for this study.

Results: A total of 120 HIV-seropositive patients were included in this study, among which 38 were diagnosed of dermatophytosis. Most patients were in the 21-30 years' age group. Tinea cruris was the most common variant, and was the most common offending pathogen. It was also found that the CD4+ T-cell count does not influence the occurrence of dermatophytoses.

Conclusion: Superficial fungal infections are a common yet significant problem in HIV infection. They are characterized by the diversity of clinical aspects; the lesions are mostly caused by . It is essential that optimum treatment should be administered.

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References

Gupta A, Taborda P, Taborda V, Gilmour J, Rachlis A, Salit I . Epidemiology and prevalence of onychomycosis in HIV-positive individuals. Int J Dermatol. 2000; 39(10):746-53. DOI: 10.1046/j.1365-4362.2000.00012.x. View

Garman M, Tyring S . The cutaneous manifestations of HIV infection. Dermatol Clin. 2002; 20(2):193-208. DOI: 10.1016/s0733-8635(01)00011-0. View

Lohoue Petmy J, Lando A, Kaptue L, Tchinda V, Folefack M . Superficial mycoses and HIV infection in Yaounde. J Eur Acad Dermatol Venereol. 2004; 18(3):301-4. DOI: 10.1111/j.1468-3083.2004.00924.x. View

Venkatesan P, Perfect J, Myers S . Evaluation and management of fungal infections in immunocompromised patients. Dermatol Ther. 2005; 18(1):44-57. DOI: 10.1111/j.1529-8019.2005.05001.x. View

Kaviarasan P, Jaisankar T, Thappa D, Sujatha S . Clinical variations in dermatophytosis in HIV infected patients. Indian J Dermatol Venereol Leprol. 2007; 68(4):213-6. View

Rodwell G, Bayles C, Towersey L, Aly R . The prevalence of dermatophyte infection in patients infected with human immunodeficiency virus. Int J Dermatol. 2008; 47(4):339-43. DOI: 10.1111/j.1365-4632.2008.03416.x. View

Cambuim I, Macedo D, Delgado M, Lima K, Mendes G, de Souza-Motta C . [Clinical and mycological evaluation of onychomycosis among Brazilian HIV/AIDS patients]. Rev Soc Bras Med Trop. 2011; 44(1):40-2. DOI: 10.1590/s0037-86822011000100010. View

Hanumanthappa H, Sarojini K, Shilpashree P, Muddapur S . Clinicomycological study of 150 cases of dermatophytosis in a tertiary care hospital in South India. Indian J Dermatol. 2012; 57(4):322-3. PMC: 3401857. DOI: 10.4103/0019-5154.97684. View

Costa J, Neves R, Delgado M, Lima-Neto R, Morais V, Coelho M . Dermatophytosis in patients with human immunodeficiency virus infection: clinical aspects and etiologic agents. Acta Trop. 2015; 150:111-5. DOI: 10.1016/j.actatropica.2015.07.012. View

10.

. Classification system for human T-lymphotropic virus type III/lymphadenopathy-associated virus infections. MMWR Morb Mortal Wkly Rep. 1986; 35(20):334-9. View

11.

Aly R, Berger T . Common superficial fungal infections in patients with AIDS. Clin Infect Dis. 1996; 22 Suppl 2:S128-32. DOI: 10.1093/clinids/22.supplement_2.s128. View

12.

Gregory N . Special patient populations: onychomycosis in the HIV-positive patient. J Am Acad Dermatol. 1996; 35(3 Pt 2):S13-6. DOI: 10.1016/s0190-9622(96)90064-x. View

13.

Cribier B, Mena M, Rey D, Partisani M, Fabien V, Lang J . Nail changes in patients infected with human immunodeficiency virus. A prospective controlled study. Arch Dermatol. 1998; 134(10):1216-20. DOI: 10.1001/archderm.134.10.1216. View