Characterization of the Myocardial Inflammatory Response in Acute Stress-Induced (Takotsubo) Cardiomyopathy

Overview

Journal JACC Basic Transl Sci

Date 2019 Jan 10

PMID 30623136

Citations 62

Authors

Heather M Wilson

Lesley Cheyne

Paul A J Brown

Keith Kerr

Andrew Hannah

Janaki Srinivasan

Natallia Duniak

Graham Horgan

Dana K Dawson

Affiliations

Soon will be listed here.

Abstract

Takotsubo cardiomyopathy is an acute stress-induced heart failure syndrome for which the exact pathogenic mechanisms are unclear, and consequently, no specific treatment exists. In an experimental model of stress-induced takotsubo-like cardiomyopathy, the authors describe the temporal course of a chronic inflammatory response post-induction, with an initial early influx of neutrophils into myocardial tissue followed by macrophages that are typical of a proinflammatory M1 phenotype, and a nonsignificant increase in systemic inflammatory cytokines. Post-mortem myocardium from the more complex clinical takotsubo patients share features of the study's experimental model. These findings suggest modulators of inflammation could be a potential therapeutic option.

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