Rosmarinus Officinalis L. (rosemary) As Therapeutic and Prophylactic Agent

Overview

Journal J Biomed Sci

Publisher Biomed Central

Specialty Biology

Date 2019 Jan 10

PMID 30621719

Citations 74

Authors

Jonatas Rafael de Oliveira

Samira Esteves Afonso Camargo

Luciane Dias de Oliveira

Affiliations

Soon will be listed here.

Abstract

Rosmarinus officinalis L. (rosemary) is a medicinal plant native to the Mediterranean region and cultivated around the world. Besides the therapeutic purpose, it is commonly used as a condiment and food preservative. R. officinalis L. is constituted by bioactive molecules, the phytocompounds, responsible for implement several pharmacological activities, such as anti-inflammatory, antioxidant, antimicrobial, antiproliferative, antitumor and protective, inhibitory and attenuating activities. Thus, in vivo and in vitro studies were presented in this Review, approaching the therapeutic and prophylactic effects of R. officinalis L. on some physiological disorders caused by biochemical, chemical or biological agents. In this way, methodology, mechanisms, results, and conclusions were described. The main objective of this study was showing that plant products could be equivalent to the available medicines.

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References

Gerweck L, Kozin S, Stocks S . The pH partition theory predicts the accumulation and toxicity of doxorubicin in normal and low-pH-adapted cells. Br J Cancer. 1999; 79(5-6):838-42. PMC: 2362684. DOI: 10.1038/sj.bjc.6690134. View

Sen P . Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials. Indian J Exp Biol. 2000; 37(2):124-30. View

Cohn J, Ferrari R, Sharpe N . Cardiac remodeling--concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J Am Coll Cardiol. 2000; 35(3):569-82. DOI: 10.1016/s0735-1097(99)00630-0. View

Landrigan P, Boffetta P, Apostoli P . The reproductive toxicity and carcinogenicity of lead: a critical review. Am J Ind Med. 2000; 38(3):231-43. DOI: 10.1002/1097-0274(200009)38:3<231::aid-ajim2>3.0.co;2-o. View

Markowitz M . Lead poisoning. Pediatr Rev. 2000; 21(10):327-35. DOI: 10.1542/pir.21-10-327. View

Green S, FREIBERG R, Giaccia A . p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest. Mol Cell Biol. 2001; 21(4):1196-206. PMC: 99573. DOI: 10.1128/MCB.21.4.1196-1206.2001. View

Lewis K . Riddle of biofilm resistance. Antimicrob Agents Chemother. 2001; 45(4):999-1007. PMC: 90417. DOI: 10.1128/AAC.45.4.999-1007.2001. View

Brognard J, Clark A, Ni Y, Dennis P . Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res. 2001; 61(10):3986-97. View

Lambert R, Skandamis P, Coote P, Nychas G . A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol. J Appl Microbiol. 2001; 91(3):453-62. DOI: 10.1046/j.1365-2672.2001.01428.x. View

10.

Helmlinger G, Sckell A, Dellian M, Forbes N, Jain R . Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism. Clin Cancer Res. 2002; 8(4):1284-91. View

11.

Yokozawa T, Nakagawa T, Kitani K . Antioxidative activity of green tea polyphenol in cholesterol-fed rats. J Agric Food Chem. 2002; 50(12):3549-52. DOI: 10.1021/jf020029h. View

12.

Liang Y, Lin-Shiau S, Ho C, Lin J . Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages. Carcinogenesis. 2002; 23(6):983-91. DOI: 10.1093/carcin/23.6.983. View

13.

Marder M, Paladini A . GABA(A)-receptor ligands of flavonoid structure. Curr Top Med Chem. 2002; 2(8):853-67. DOI: 10.2174/1568026023393462. View

14.

Iavicoli I, Carelli G, Stanek E, Castellino N, Calabrese E . Effects of low doses of dietary lead on red blood cell production in male and female mice. Toxicol Lett. 2003; 137(3):193-9. DOI: 10.1016/s0378-4274(02)00404-6. View

15.

Mohindra J, Rauth A . Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells. Cancer Res. 1976; 36(3):930-6. View

16.

Akhondzadeh S, Kashani L, Fotouhi A, Jarvandi S, Mobaseri M, Moin M . Comparison of Lavandula angustifolia Mill. tincture and imipramine in the treatment of mild to moderate depression: a double-blind, randomized trial. Prog Neuropsychopharmacol Biol Psychiatry. 2003; 27(1):123-7. DOI: 10.1016/s0278-5846(02)00342-1. View

17.

Hosseinzadeh H, Nourbakhsh M . Effect of Rosmarinus officinalis L. aerial parts extract on morphine withdrawal syndrome in mice. Phytother Res. 2003; 17(8):938-41. DOI: 10.1002/ptr.1311. View

18.

Mahoney B, Raghunand N, Baggett B, Gillies R . Tumor acidity, ion trapping and chemotherapeutics. I. Acid pH affects the distribution of chemotherapeutic agents in vitro. Biochem Pharmacol. 2003; 66(7):1207-18. DOI: 10.1016/s0006-2952(03)00467-2. View

19.

Koch S, Mayer F, Honecker F, Schittenhelm M, Bokemeyer C . Efficacy of cytotoxic agents used in the treatment of testicular germ cell tumours under normoxic and hypoxic conditions in vitro. Br J Cancer. 2003; 89(11):2133-9. PMC: 2376846. DOI: 10.1038/sj.bjc.6601375. View

20.

Vaupel P . Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol. 2004; 14(3):198-206. DOI: 10.1016/j.semradonc.2004.04.008. View