A Review of Oxygen Use During Chest Compressions in Newborns-A Meta-Analysis of Animal Data

Overview

Journal Front Pediatr

Specialty Pediatrics

Date 2019 Jan 9

PMID 30619794

Citations 14

Authors

Catalina Garcia-Hidalgo

Po-Yin Cheung

Anne Lee Solevag

Maximo Vento

Megan OReilly

Ola Saugstad

Georg M Schmolzer

Affiliations

Soon will be listed here.

Abstract

International consensus statements for resuscitation of newborn infants recommend provision of 100% oxygen once chest compressions are required. However, 100% oxygen exacerbates reperfusion injury and reduces cerebral perfusion in newborn babies. We aimed to establish whether resuscitation with air during chest compression is feasible and safe in newborn infants compared with 100% oxygen. Systematic search of PubMed, Google Scholar and CINAHL for articles examining variable oxygen concentrations during chest compressions in term newborns. Overall, no human studies but eight animal studies ( = 323 animals) comparing various oxygen concentrations during chest compression were identified. The pooled analysis showed no difference in mortality rates for animals resuscitated with air vs. 100% oxygen (risk ratio 1.04 [0.35, 3.08], I = 0%, = 0.94). ROSC was also similar between groups with a mean difference of -3.8 [-29.7-22] s, I = 0%, = 0.77. No difference in oxygen damage or adverse events were identified between groups. Air had similar time to ROSC and mortality as 100% oxygen during neonatal chest compression. A large randomized controlled clinical trial comparing air vs. 100% oxygen during neonatal chest compression is warranted.

Citing Articles

Optimal oxygen use in neonatal advanced cardiopulmonary resuscitation-a literature review.

Sankaran D, Rawat M, Lakshminrusimha S Pediatr Med. 2024; 6.

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Treatments and therapeutic protocols for the recovery of an asphyxiated new-born: A review of pre-clinical and clinical studies in human neonates and in different animal models.

Islas-Fabila P, Orozco-Gregorio H, Roldan-Santiago P, Waytula M, Gonzalez-Hernandez M, Vega-Manriquez X Vet Med (Praha). 2024; 67(6):271-297.

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Chest compression rates of 60/min versus 90/min during neonatal cardiopulmonary resuscitation: a randomized controlled animal trial.

Bruckner M, OReilly M, Lee T, Cheung P, Schmolzer G Front Pediatr. 2023; 11:1214513.

PMID: 37664554 PMC: 10468595. DOI: 10.3389/fped.2023.1214513.

Randomized Trial of 21% versus 100% Oxygen during Chest Compressions Followed by Gradual versus Abrupt Oxygen Titration after Return of Spontaneous Circulation in Neonatal Lambs.

Sankaran D, Giusto E, Lesneski A, Hardie M, Joudi H, Lane E Children (Basel). 2023; 10(3).

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Four Different Finger Positions and Their Effects on Hemodynamic Changes during Chest Compression in Asphyxiated Neonatal Piglets.

Bruckner M, Neset M, OReilly M, Lee T, Cheung P, Schmolzer G Children (Basel). 2023; 10(2).

PMID: 36832412 PMC: 9954809. DOI: 10.3390/children10020283.

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