Structural Changes Observed in the Piriform Cortex in a Rat Model of Pre-motor Parkinson's Disease

Overview

Journal Front Cell Neurosci

Specialty Cell Biology

Date 2019 Jan 9

PMID 30618629

Citations 11

Authors

Marco Sancandi

Emma Victoria Schul

Georgia Economides

Andrew Constanti

Audrey Mercer

Affiliations

Soon will be listed here.

Abstract

Early diagnosis of Parkinson's disease (PD) offers perhaps, the most promising route to a successful clinical intervention, and the use of an animal model exhibiting symptoms comparable to those observed in PD patients in the early stage of the disease, may facilitate screening of novel therapies for delaying the onset of more debilitating motor and behavioral abnormalities. In this study, a rat model of pre-motor PD was used to study the etiology of hyposmia, a non-motor symptom linked to the early stage of the disease when the motor symptoms have yet to be experienced. The study focussed on determining the effect of a partial reduction of both dopamine and noradrenaline levels on the olfactory cortex. Neuroinflammation and striking structural changes were observed in the model. These changes were prevented by treatment with a neuroprotective drug, a glucagon-like peptide-1 (GLP1) receptor agonist, exendin-4 (EX-4).

Citing Articles

Chemosensory Impairments and Their Impact on Nutrition in Parkinson's Disease: A Narrative Literature Review.

Alia S, Andrenelli E, Di Paolo A, Membrino V, Mazzanti L, Capecci M Nutrients. 2025; 17(4).

PMID: 40004999 PMC: 11858080. DOI: 10.3390/nu17040671.

Brain-Region-Specific Differences in Protein Citrullination/Deimination in a Pre-Motor Parkinson's Disease Rat Model.

Mercer A, Sancandi M, Maclatchy A, Lange S Int J Mol Sci. 2024; 25(20).

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Damage to the Locus Coeruleus Alters the Expression of Key Proteins in Limbic Neurodegeneration.

Biagioni F, Ferrucci M, Lazzeri G, Scioli M, Frati A, Puglisi-Allegra S Int J Mol Sci. 2024; 25(6).

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Effects of a probiotic suspension Symprove™ on a rat early-stage Parkinson's disease model.

Sancandi M, De Caro C, Cypaite N, Marascio N, Avagliano C, De Marco C Front Aging Neurosci. 2023; 14:986127.

PMID: 36742204 PMC: 9890174. DOI: 10.3389/fnagi.2022.986127.

The Potential of to Predict Parkinson's Disease.

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