Radiation-responsive Scintillating Nanotheranostics for Reduced Hypoxic Radioresistance Under ROS/NO-mediated Tumor Microenvironment Regulation

Overview

Journal Theranostics

Date 2019 Jan 8

PMID 30613268

Citations 18

Authors

Yan Dou

Yajuan Liu

Fangshi Zhao

Yanyan Guo

Xue Li

Menglin Wu

Jin Chang

Chunshui Yu

Affiliations

Soon will be listed here.

Abstract

Methods: Herein, we explored a radiation-responsive nanotheranostic system to enhance RT effects on hypoxic tumors by multi-way therapeutic effects. This system was developed by loading S-nitrosothiol groups (SNO, a NO donor) and indocyanine green (ICG, a photosensitizer) onto mesoporous silica shells of Eu-doped NaGdF scintillating nanocrystals (NSC).

Results: Under X-ray radiation, this system can increase the local dosage by high-Z elements, promote ROS generation by X-ray-induced photodynamic therapy, and produce high levels of NO to enhance tumor-killing effects and improve hypoxia NO-induced vasodilation. and studies revealed that this combined strategy can greatly reinforce DNA damage and apoptosis of hypoxic tumor cells, while significantly suppressing tumor growth, improving tumor hypoxia and promoting p53 up-regulation and HIF1α down-regulation. In addition, this system showed pronounced tumor contrast performance in T-weighted magnetic resonance imaging and computed tomography.

Conclusion: This work demonstrates the great potential of scintillating nanotheranostics for multimodal imaging-guided X-ray radiation-triggered tumor combined therapy to overcome radioresistance.

Citing Articles

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