Pitch of Harmonic Complex Tones: Rate Coding of Envelope Repetition Rate in the Auditory Midbrain

Overview

Journal Acta Acust United Acust

Publisher EDP Sciences

Date 2019 Jan 8

PMID 30613198

Citations 1

Authors

Yaqing Su

Bertrand Delgutte

Affiliations

Soon will be listed here.

Abstract

Envelope repetition rate (ERR) is an important cue for the pitch of harmonic complex tones (HCT), especially when the tone consists entirely of unresolved harmonics. Neural synchronization to the stimulus envelope provides a prominent cue for ERR in the auditory periphery, but this temporal code becomes degraded and gives way to rate codes in higher centers. The inferior colliculus (IC) likely plays a key role in this temporal-to-rate code transformation. Here we recorded single IC neuron responses to HCT at varying fundamental frequencies ( ). ERR was manipulated by applying different inter-harmonic phase relationships. We identified a subset of neurons that showed a 'non-tonotopic' rate tuning to ERR between 160 and 1500 Hz. A comparison of neural responses to HCT and sinusoidally amplitude modulated (SAM) noise suggests that this tuning is dependent on the shape of stimulus envelope. A phenomenological model is able to reproduce the non-tonotopic tuning to ERR, and suggests it arises in the IC via synaptic inhibition.

Citing Articles

Pitch of harmonic complex tones: rate and temporal coding of envelope repetition rate in inferior colliculus of unanesthetized rabbits.

Su Y, Delgutte B J Neurophysiol. 2019; 122(6):2468-2485.

PMID: 31664871 PMC: 6966312. DOI: 10.1152/jn.00512.2019.

References

Shackleton T, Liu L, Palmer A . Responses to diotic, dichotic, and alternating phase harmonic stimuli in the inferior colliculus of guinea pigs. J Assoc Res Otolaryngol. 2008; 10(1):76-90. PMC: 2644390. DOI: 10.1007/s10162-008-0149-4. View

Nelson P, Carney L . Neural rate and timing cues for detection and discrimination of amplitude-modulated tones in the awake rabbit inferior colliculus. J Neurophysiol. 2006; 97(1):522-39. PMC: 2577033. DOI: 10.1152/jn.00776.2006. View

Cedolin L, Delgutte B . Pitch of complex tones: rate-place and interspike interval representations in the auditory nerve. J Neurophysiol. 2005; 94(1):347-62. PMC: 2094528. DOI: 10.1152/jn.01114.2004. View

Wagner J, Gelman A, Hancock K, Chung Y, Delgutte B . Rabbits use both spectral and temporal cues to discriminate the fundamental frequency of harmonic complexes with missing fundamentals. J Neurophysiol. 2021; 127(1):290-312. PMC: 8759963. DOI: 10.1152/jn.00366.2021. View

Zuk N, Delgutte B . Neural coding of time-varying interaural time differences and time-varying amplitude in the inferior colliculus. J Neurophysiol. 2017; 118(1):544-563. PMC: 5511866. DOI: 10.1152/jn.00797.2016. View

Nelson P, Carney L . A phenomenological model of peripheral and central neural responses to amplitude-modulated tones. J Acoust Soc Am. 2004; 116(4 Pt 1):2173-86. PMC: 1379629. DOI: 10.1121/1.1784442. View

Joris P, Schreiner C, Rees A . Neural processing of amplitude-modulated sounds. Physiol Rev. 2004; 84(2):541-77. DOI: 10.1152/physrev.00029.2003. View

Carney L, Li T, McDonough J . Speech Coding in the Brain: Representation of Vowel Formants by Midbrain Neurons Tuned to Sound Fluctuations. eNeuro. 2015; 2(4). PMC: 4596011. DOI: 10.1523/ENEURO.0004-15.2015. View

Shackleton T, Carlyon R . The role of resolved and unresolved harmonics in pitch perception and frequency modulation discrimination. J Acoust Soc Am. 1994; 95(6):3529-40. DOI: 10.1121/1.409970. View

10.

Schnupp J, Garcia-Lazaro J, Lesica N . Periodotopy in the gerbil inferior colliculus: local clustering rather than a gradient map. Front Neural Circuits. 2015; 9:37. PMC: 4550179. DOI: 10.3389/fncir.2015.00037. View

11.

Sinex D, Henderson J, Li H, Chen G . Responses of chinchilla inferior colliculus neurons to amplitude-modulated tones with different envelopes. J Assoc Res Otolaryngol. 2002; 3(4):390-402. PMC: 3202442. DOI: 10.1007/s101620020026. View

12.

Cariani P, Delgutte B . Neural correlates of the pitch of complex tones. I. Pitch and pitch salience. J Neurophysiol. 1996; 76(3):1698-716. DOI: 10.1152/jn.1996.76.3.1698. View

13.

Zheng Y, Escabi M . Distinct roles for onset and sustained activity in the neuronal code for temporal periodicity and acoustic envelope shape. J Neurosci. 2008; 28(52):14230-44. PMC: 2636849. DOI: 10.1523/JNEUROSCI.2882-08.2008. View

14.

Moore B . The role of temporal fine structure processing in pitch perception, masking, and speech perception for normal-hearing and hearing-impaired people. J Assoc Res Otolaryngol. 2008; 9(4):399-406. PMC: 2580810. DOI: 10.1007/s10162-008-0143-x. View

15.

Krebs B, Lesica N, Grothe B . The representation of amplitude modulations in the mammalian auditory midbrain. J Neurophysiol. 2008; 100(3):1602-9. DOI: 10.1152/jn.90374.2008. View

16.

Bendor D, Wang X . The neuronal representation of pitch in primate auditory cortex. Nature. 2005; 436(7054):1161-5. PMC: 1780171. DOI: 10.1038/nature03867. View

17.

Cedolin L, Delgutte B . Spatiotemporal representation of the pitch of harmonic complex tones in the auditory nerve. J Neurosci. 2010; 30(38):12712-24. PMC: 2957107. DOI: 10.1523/JNEUROSCI.6365-09.2010. View

18.

Heffner H, Heffner R . Hearing ranges of laboratory animals. J Am Assoc Lab Anim Sci. 2007; 46(1):20-2. View