Precision Medicine in Weight Loss and Healthy Living

Overview

Journal Prog Cardiovasc Dis

Specialty Cardiology & Vascular Diseases

Date 2019 Jan 6

PMID 30610881

Citations 16

Authors

Richard Severin

Ahmad Sabbahi

Abeer M Mahmoud

Ross Arena

Shane A Phillips

Affiliations

Soon will be listed here.

Abstract

Obesity affects 600 million people globally and over one third of the American population. Along with associated comorbidities, including cardiovascular disease, stroke, diabetes, and cancer; the direct and indirect costs of managing obesity are 21% of the total medical costs. These factors shed light on why developing effective and pragmatic strategies to reduce body weight in obese individuals is a major public health concern. An estimated 60-70% of obese Americans attempt to lose weight each year, with only a small minority able to achieve and maintain long term weight loss. To address this issue a precision medicine approach for weight loss has been considered, which places an emphasis on sustainability and real-world application to individualized therapy. In this article we review weight loss interventions in the context of precision medicine and discuss the role of genetic and epigenetic factors, pharmacological interventions, lifestyle interventions, and bariatric surgery on weight loss.

Citing Articles

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Trends and Disparities in Diet Quality and Nutrient Intake among US Adults by Bodyweight Status.

Gu W, Yang Y, Wang L, Song Y, Yan X, Tian Z Nutrients. 2024; 16(16).

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A Predictive Tool Based on DNA Methylation Data for Personalized Weight Loss through Different Dietary Strategies: A Pilot Study.

Garcia-Alvarez N, Riezu-Boj J, Martinez J, Garcia-Calzon S, Milagro F Nutrients. 2023; 15(24).

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Patterns and Predictors of Engagement With Digital Self-Monitoring During the Maintenance Phase of a Behavioral Weight Loss Program: Quantitative Study.

Crane N, Hagerman C, Horgan O, Butryn M JMIR Mhealth Uhealth. 2023; 11:e45057.

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