A Modified Physiologic Test for Bronchopulmonary Dysplasia: a Clinical Tool for Weaning from CPAP And/or Oxygen-therapy the Premature Babies?

Overview

Journal Ital J Pediatr

Publisher Biomed Central

Specialty Pediatrics

Date 2019 Jan 6

PMID 30609929

Citations 3

Authors

Giovanni Vento

Valentina Vendettuoli

Claudia Aurilia

Milena Tana

Chiara Tirone

Alessandra Lio

Piero Giuseppe Matassa

Francesca Priolo

Piero Catenazzi

Mirta Corsello

Enrico Zecca

Fabio Mosca

Affiliations

Soon will be listed here.

Abstract

Background: A physiologic test for estimating BPD rate has been developed by Walsh and collaborators. Actually there are not standard criteria for weaning from CPAP and/or oxygen therapy the premature babies. Aim of this study was to verify if a physiologic test, modified respect to that developed by Walsh and collaborators for estimating BPD rate, can be used as a clinical tool for weaning the premature babies from CPAP and/or oxygen therapy.

Methods: Neonates with BW 500-1250 g and GA ≤ 32 weeks, receiving FiO ≤ 0.30 by hood or CPAP, were prospectively studied at 28 days of life and at 36 weeks of postmestrual age. The test was performed in 3 steps: baseline, challenge (FiO and CPAP reduction to room air) and post test (room air). Monitoring of transcutaneous CO was added to SpO and the newborns passing the test were left in room air.

Results: Six of 23 tested babies (26%) passed the challenge at 28 days of life, 4 of 10 tested babies (40%) passed the challenge at 36 weeks. Median values of SpO were significantly higher in the neonates passing the test, respect to the failing patients. At the same time median values of TcPCO were significantly higher in the latter babies.

Conclusion: TcPCO monitoring appeared to be a new useful parameter for failure prediction of weaning. The test represented a clinical guide because the newborns passing it were left in room air.

Citing Articles

Noninvasive Monitoring Strategies for Bronchopulmonary Dysplasia or Post-Prematurity Respiratory Disease: Current Challenges and Future Prospects.

Zini T, Miselli F, Berardi A Children (Basel). 2023; 10(11).

PMID: 38002844 PMC: 10670116. DOI: 10.3390/children10111753.

Pathophysiologically Based Ventilatory Management of Severe Bronchopulmonary Dysplasia.

Ozkan H, Duman N, Tuzun F Turk Arch Pediatr. 2022; 57(4):385-390.

PMID: 35822469 PMC: 9322119. DOI: 10.5152/TurkArchPediatr.2022.22112.

Advances in paediatrics in 2019: current practices and challenges in allergy, endocrinology, gastroenterology, public health, neonatology, nutrition, nephrology, neurology, respiratory diseases and rheumatic diseases.

Caffarelli C, Santamaria F, Mirra V, Bacchini E, Santoro A, Bernasconi S Ital J Pediatr. 2020; 46(1):89.

PMID: 32600434 PMC: 7325159. DOI: 10.1186/s13052-020-00853-0.

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