Prognostic Role of Preoperative Platelet, Fibrinogen, and D-dimer Levels in Patients with Non-small Cell Lung Cancer: A Multicenter Prospective Study

Overview

Journal Thorac Cancer

Specialties Oncology
Pulmonary Medicine

Date 2019 Jan 5

PMID 30609303

Citations 27

Authors

Can Hou

Feng Jiang

Haitao Ma

Quan Zhu

Zhonglin Wang

Biao Zhao

Tao Xue

Sheng Tan

Rusong Yang

Yongxiang Qian

Xuan Luo

Ming Zhao

Xing Xu

Liang Chen

Jiayuan Li

Affiliations

Soon will be listed here.

Abstract

Background: The relationships between coagulation factors and non-small cell lung cancer (NSCLC) prognosis have been intensively studied. However, no previous study has investigated the combined effects of preoperative platelet (PLT), fibrinogen (FIB), and D-dimer (D-D) levels on the prognosis of NSCLC.

Methods: A multicenter prospective study was conducted over seven hospitals. A total of 395 patients diagnosed with operable NSCLC for the first time were included and followed-up until disease progression or the end of the study. Baseline demographic and clinicopathological information, and preoperative coagulation test results were collected for each patient. Univariate and multilevel survival analyses were conducted using Cox regression and shared frailty models.

Results: Multilevel analyses revealed that there was a marginally significant association between elevated PLT level (> 215 × 10 /L) and unfavorable progression-free survival (PFS) (hazard ratio 2.42, P = 0.05), whereas preoperative FIB and D-D were not significant prognostic factors for PFS (P = 0.31 and 0.30, respectively). Compared to patients with one elevation of the three coagulation factors, patients with at least two elevations of the three factors had a significantly higher risk of cancer progression (hazard ratio 4.62, P = 0.02).

Conclusion: The number of elevated preoperative coagulation factors may have a significant effect on PFS and could be used to predict the prognosis of NSCLC patients after surgery. Future studies are warranted to further investigate the interactions between these three coagulation factors.

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