Appropriate Treatment Receipt After Breast-conserving Surgery

Overview

Journal Curr Oncol

Publisher MDPI

Specialty Oncology

Date 2019 Jan 5

PMID 30607122

Citations 2

Authors

K Guidolin

M Lock

K Vogt

J A McClure

J Winick-Ng

C Vinden

M Brackstone

Affiliations

Soon will be listed here.

Abstract

Background: Breast-conserving surgery (bcs) and radiation therapy (rt) are the standard of care for early breast cancer, although some women receive ipsilateral mastectomy or adjuvant tamoxifen, both of which can be appropriate alternatives to rt. Objectives of the present study were to determine the proportion of women who are treated appropriately after bcs and to identify factors associated with non-receipt of rt.

Methods: This retrospective cohort study used Ontario data linked at the Institute for Clinical and Evaluative Sciences to examine 33,718 patients who received bcs during 2004-2010. Primary outcome was rt receipt. The ipsilateral mastectomy rate and patient, surgeon, and setting variables were measured.

Results: Of the study patients, 86.1% received either rt or completion mastectomy; in the cohort less than 70 years of age, 90.8% received rt or completion mastectomy. Among patients less than 70 years of age, 3 risk factors for non-receipt of rt were identified: age less than 46 years, treatment in a non-academic institution, and earlier year of initial bcs. Additionally, in the overall cohort, rt non-receipt was associated with high comorbidity, more than 40 km to the cancer centre, income quintile, and breast care specialization.

Conclusions: In Ontario, 90.8% of patients less than 70 years of age are appropriately treated for early breast cancer; approximately 1 in 10 do not receive rt or completion mastectomy. Based on those findings, women less than 46 years of age might be at increased risk of recurrence and death because of incomplete treatment. It also appears that academic centres more effectively treat breast cancer; however, breast cancer care appears to be improving over time in Ontario.

Citing Articles

Qualitative exploration of patients' experiences with Intrabeam TARGeted Intraoperative radioTherapy (TARGIT-IORT) and External-Beam RadioTherapy Treatment (EBRT) for breast cancer.

Bagga S, Swiderska N, Hooker C, Royle J, Ennis-OConnor M, Freeney S BMJ Open. 2024; 14(8):e081222.

PMID: 39164104 PMC: 11337679. DOI: 10.1136/bmjopen-2023-081222.

Recurrence and mortality after breast-conserving surgery without radiation.

Guidolin K, Lock M, Vogt K, McClure J, Winick-Ng J, Vinden C Curr Oncol. 2020; 26(6):380-388.

PMID: 31896936 PMC: 6927776. DOI: 10.3747/co.26.5225.

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