Fundus Autofluorescence Changes in Age-related Maculopathy

Overview

Journal Turk J Ophthalmol

Specialty Ophthalmology

Date 2019 Jan 5

PMID 30605937

Citations 3

Authors

Pinar Bingol Kiziltunc

Figen Sermet

Affiliations

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Abstract

Objectives: The aim of this study was to describe the fundus autofluorescence (FAF) findings of age-related maculopathy and risk patterns associated with FAF changes.

Materials And Methods: FAF images of 150 eyes with age-related maculopathy were evaluated retrospectively. FAF patterns were classified as normal, minimal change, focal increase, patchy, linear, lace-like, reticular, and speckled pattern. Correlation between patterns and visual acuity, pattern associations at initial visit, and focal atrophy development and pattern alterations during follow-up were evaluated.

Results: At initial examination, 33.3% of the eyes showed no FAF pattern. In the other eyes, the most common patterns were reticular, focal increase, and patchy pattern at rates of 18%, 14.7%, and 11.3%, respectively. There was no correlation between pattern and visual acuity at initial visit. Two coexisting patterns were observed in 4.6% eyes, and the most common pattern in these combinations was reticular pattern (85.7%). Pattern alterations were observed in 5.3% of the eyes during follow-up. Half of these alterations involved transformation to reticular pattern or addition of reticular pattern to the initial pattern. In addition, 13.3% of the eyes developed focal atrophy during follow-up. Development of focal atrophy was more common with focal increase and reticular pattern, with rates of 45% and 30%, respectively.

Conclusion: Presence of reticular pattern may be a risk factor for change and progression of FAF findings in age-related maculopathy.

Citing Articles

Non-Neovascular Age-Related Macular Degeneration Assessment: Focus on Optical Coherence Tomography Biomarkers.

Iliescu D, Ghita A, Ilie L, Voiculescu S, Geamanu A, Ghita A Diagnostics (Basel). 2024; 14(7).

PMID: 38611677 PMC: 11011935. DOI: 10.3390/diagnostics14070764.

The Use of Fundus Autofluorescence in Dry Age-Related Macular Degeneration.

Keskek N, Sermet F Turk J Ophthalmol. 2021; 51(3):169-176.

PMID: 34187152 PMC: 8251671. DOI: 10.4274/tjo.galenos.2020.49107.

Five-year follow-up of fundus autofluorescence and retinal sensitivity in the fellow eye in exudative age-related macular degeneration in Japan.

Shinojima A, Sawa M, Mori R, Sekiryu T, Oshima Y, Kato A PLoS One. 2020; 15(3):e0229694.

PMID: 32142523 PMC: 7059919. DOI: 10.1371/journal.pone.0229694.

References

Cachulo L, Silva R, Fonseca P, Pires I, Carvajal-Gonzalez S, Bernardes R . Early markers of choroidal neovascularization in the fellow eye of patients with unilateral exudative age-related macular degeneration. Ophthalmologica. 2010; 225(3):144-9. DOI: 10.1159/000321064. View

De Bats F, Mathis T, Mauget-Faysse M, Joubert F, Denis P, Kodjikian L . PREVALENCE OF RETICULAR PSEUDODRUSEN IN AGE-RELATED MACULAR DEGENERATION USING MULTIMODAL IMAGING. Retina. 2015; 36(1):46-52. DOI: 10.1097/IAE.0000000000000648. View

Bindewald A, Bird A, Dandekar S, Dolar-Szczasny J, Dreyhaupt J, Fitzke F . Classification of fundus autofluorescence patterns in early age-related macular disease. Invest Ophthalmol Vis Sci. 2005; 46(9):3309-14. DOI: 10.1167/iovs.04-0430. View

Arnold J, Sarks S, Killingsworth M, Sarks J . Reticular pseudodrusen. A risk factor in age-related maculopathy. Retina. 1995; 15(3):183-91. View

Klein R, Meuer S, Knudtson M, Iyengar S, Klein B . The epidemiology of retinal reticular drusen. Am J Ophthalmol. 2007; 145(2):317-326. PMC: 2258433. DOI: 10.1016/j.ajo.2007.09.008. View

Attebo K, Mitchell P, Smith W . Visual acuity and the causes of visual loss in Australia. The Blue Mountains Eye Study. Ophthalmology. 1996; 103(3):357-64. DOI: 10.1016/s0161-6420(96)30684-2. View

Delori F, Fleckner M, Goger D, Weiter J, Dorey C . Autofluorescence distribution associated with drusen in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2000; 41(2):496-504. View

Bird A . Bruch's membrane change with age. Br J Ophthalmol. 1992; 76(3):166-8. PMC: 504197. DOI: 10.1136/bjo.76.3.166. View

Marsiglia M, Boddu S, Bearelly S, Xu L, Breaux Jr B, Freund K . Association between geographic atrophy progression and reticular pseudodrusen in eyes with dry age-related macular degeneration. Invest Ophthalmol Vis Sci. 2013; 54(12):7362-9. PMC: 3823546. DOI: 10.1167/iovs.12-11073. View

10.

Kellner U, Kellner S, Weinitz S . Fundus autofluorescence (488 NM) and near-infrared autofluorescence (787 NM) visualize different retinal pigment epithelium alterations in patients with age-related macular degeneration. Retina. 2010; 30(1):6-15. DOI: 10.1097/iae.0b013e3181b8348b. View

11.

Bressler S, Maguire M, Bressler N, Fine S . Relationship of drusen and abnormalities of the retinal pigment epithelium to the prognosis of neovascular macular degeneration. The Macular Photocoagulation Study Group. Arch Ophthalmol. 1990; 108(10):1442-7. DOI: 10.1001/archopht.1990.01070120090035. View

12.

Silva R, Cachulo M, Fonseca P, Bernardes R, Nunes S, Vilhena N . Age-related macular degeneration and risk factors for the development of choroidal neovascularisation in the fellow eye: a 3-year follow-up study. Ophthalmologica. 2011; 226(3):110-8. DOI: 10.1159/000329473. View

13.

Wilde C, Patel M, Lakshmanan A, Morales M, Dhar-Munshi S, Amoaku W . Prevalence of reticular pseudodrusen in eyes with newly presenting neovascular age-related macular degeneration. Eur J Ophthalmol. 2015; 26(2):128-34. DOI: 10.5301/ejo.5000661. View

14.

Zweifel S, Imamura Y, Spaide T, Fujiwara T, Spaide R . Prevalence and significance of subretinal drusenoid deposits (reticular pseudodrusen) in age-related macular degeneration. Ophthalmology. 2010; 117(9):1775-81. DOI: 10.1016/j.ophtha.2010.01.027. View

15.

Klaver C, Wolfs R, Vingerling J, Hofman A, de Jong P . Age-specific prevalence and causes of blindness and visual impairment in an older population: the Rotterdam Study. Arch Ophthalmol. 1998; 116(5):653-8. DOI: 10.1001/archopht.116.5.653. View

16.

Knudtson M, Klein R, Klein B, Lee K, Meuer S, Tomany S . Location of lesions associated with age-related maculopathy over a 10-year period: the Beaver Dam Eye Study. Invest Ophthalmol Vis Sci. 2004; 45(7):2135-42. DOI: 10.1167/iovs.03-1085. View

17.

Lois N, Owens S, Coco R, Hopkins J, Fitzke F, Bird A . Fundus autofluorescence in patients with age-related macular degeneration and high risk of visual loss. Am J Ophthalmol. 2002; 133(3):341-9. DOI: 10.1016/s0002-9394(01)01404-0. View

18.

Xuan Y, Zhao P, Peng Q . [Fundus autofluorescence patterns of drusen in age-related macular degeneration]. Zhonghua Yan Ke Za Zhi. 2010; 46(8):708-13. View

19.

Sarks J, Arnold J, Ho I, Sarks S, Killingsworth M . Evolution of reticular pseudodrusen. Br J Ophthalmol. 2010; 95(7):979-85. DOI: 10.1136/bjo.2010.194977. View

20.

Finger R, Wu Z, Luu C, Kearney F, Ayton L, Lucci L . Reticular pseudodrusen: a risk factor for geographic atrophy in fellow eyes of individuals with unilateral choroidal neovascularization. Ophthalmology. 2014; 121(6):1252-6. PMC: 4047161. DOI: 10.1016/j.ophtha.2013.12.034. View