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Interictal Spike Connectivity in Human Epileptic Neocortex

Overview
Publisher Elsevier
Specialties Neurology
Psychiatry
Date 2019 Jan 4
PMID 30605889
Citations 17
Authors
Affiliations
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Abstract

Objective: Interictal spikes are a biomarker of epilepsy, yet their precise roles are poorly understood. Using long-term neocortical recordings from epileptic patients, we investigated the spatial-temporal propagation patterns of interictal spiking.

Methods: Interictal spikes were detected in 10 epileptic patients. Short time direct directed transfer function was used to map the spatial-temporal patterns of interictal spike onset and propagation across different cortical topographies.

Results: Each patient had unique interictal spike propagation pattern that was highly consistent across times, regardless of the frequency band. High spiking brain regions were often not spike onset regions. We observed frequent spike propagations to shorter distances and that the central sulcus forms a strong barrier to spike propagation. Spike onset and seizure onset seemed to be distinct networks in most cases.

Conclusions: Patients in epilepsy have distinct and unique network of causal propagation pattern which are very consistent revealing the underlying epileptic network. Although spike are epileptic biomarkers, spike origin and seizure onset seems to be distinct in most cases.

Significance: Understanding patterns of interictal spike propagation could lead to the identification patient-specific epileptic networks amenable to surgical or other treatments.

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Schmid W, Danstrom I, Crespo Echevarria M, Adkinson J, Mattar L, Banks G J Neurosci Methods. 2024; 405:110106.

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References
1.
Bartolomei F, Trebuchon A, Bonini F, Lambert I, Gavaret M, Woodman M . What is the concordance between the seizure onset zone and the irritative zone? A SEEG quantified study. Clin Neurophysiol. 2015; 127(2):1157-1162. DOI: 10.1016/j.clinph.2015.10.029. View

2.
Fischl B, Dale A . Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci U S A. 2000; 97(20):11050-5. PMC: 27146. DOI: 10.1073/pnas.200033797. View

3.
Jacobs J, Levan P, Chander R, Hall J, Dubeau F, Gotman J . Interictal high-frequency oscillations (80-500 Hz) are an indicator of seizure onset areas independent of spikes in the human epileptic brain. Epilepsia. 2008; 49(11):1893-907. PMC: 3792077. DOI: 10.1111/j.1528-1167.2008.01656.x. View

4.
Alarcon G, Seoane J, Binnie C, Martin Miguel M, Juler J, Polkey C . Origin and propagation of interictal discharges in the acute electrocorticogram. Implications for pathophysiology and surgical treatment of temporal lobe epilepsy. Brain. 1998; 120 ( Pt 12):2259-82. DOI: 10.1093/brain/120.12.2259. View

5.
Nariai H, Nagasawa T, Juhasz C, Sood S, Chugani H, Asano E . Statistical mapping of ictal high-frequency oscillations in epileptic spasms. Epilepsia. 2010; 52(1):63-74. PMC: 3051422. DOI: 10.1111/j.1528-1167.2010.02786.x. View