Model-based Lesion Mapping of Cognitive Control Using the Wisconsin Card Sorting Test

Overview

Journal Nat Commun

Specialty Biology

Date 2019 Jan 4

PMID 30604744

Citations 29

Authors

Jan Glascher

Ralph Adolphs

Daniel Tranel

Affiliations

Soon will be listed here.

Abstract

The role of the frontal lobes in cognition and behavior has long been enigmatic. Over the past decade, computational models have provided a powerful approach to understanding cognition and decision-making. Here, we used a model-based approach to analyze data from a classical task used to assess frontal lobe function, the Wisconsin Card Sorting Test. We applied computational modeling and voxel-based lesion-symptom mapping in 328 patients with focal lesions, to uncover cognitive processes and neural correlates of test scores. Our results reveal that lesions in the right prefrontal cortex are associated with elevated perseverative errors and reductions in the model parameter of sensitivity to punishment. These findings indicate that the capacity to flexibly switch between task sets requires the detection of contingency changes, which are enabled by a sensitivity to punishment that reduces perseverative errors. We demonstrate the power of model-based approaches in understanding patterns of deficits on classical neuropsychological tasks.

Citing Articles

Mapping computational cognitive profiles of aging to dissociable brain and sociodemographic factors.

Marzuki A, Wong K, Chan J, Na S, Thanaraju A, Phon-Amnuaisuk P NPJ Aging. 2024; 10(1):50.

PMID: 39482289 PMC: 11527976. DOI: 10.1038/s41514-024-00171-3.

Improving working memory by electrical stimulation and cross-frequency coupling.

Al Qasem W, Abubaker M, Pilatova K, Jezdik P, Kvasnak E Mol Brain. 2024; 17(1):72.

PMID: 39354549 PMC: 11446076. DOI: 10.1186/s13041-024-01142-1.

A Comparison of Rapid Rule-Learning Strategies in Humans and Monkeys.

Goudar V, Kim J, Liu Y, Dede A, Jutras M, Skelin I J Neurosci. 2024; 44(28.

PMID: 38871463 PMC: 11236592. DOI: 10.1523/JNEUROSCI.0231-23.2024.

Mixtures of strategies underlie rodent behavior during reversal learning.

Le N, Yildirim M, Wang Y, Sugihara H, Jazayeri M, Sur M PLoS Comput Biol. 2023; 19(9):e1011430.

PMID: 37708113 PMC: 10501641. DOI: 10.1371/journal.pcbi.1011430.

Using predictive validity to compare associations between brain damage and behavior.

Magnotti J, Patterson J, Schnur T Hum Brain Mapp. 2023; 44(13):4738-4753.

PMID: 37417774 PMC: 10400786. DOI: 10.1002/hbm.26413.

References

Volz H, Gaser C, Hager F, Rzanny R, Mentzel H, Kreitschmann-Andermahr I . Brain activation during cognitive stimulation with the Wisconsin Card Sorting Test--a functional MRI study on healthy volunteers and schizophrenics. Psychiatry Res. 1998; 75(3):145-57. DOI: 10.1016/s0925-4927(97)00053-x. View

Glascher J, Tranel D, Paul L, Rudrauf D, Rorden C, Hornaday A . Lesion mapping of cognitive abilities linked to intelligence. Neuron. 2009; 61(5):681-91. PMC: 2728583. DOI: 10.1016/j.neuron.2009.01.026. View

Jurado M, Rosselli M . The elusive nature of executive functions: a review of our current understanding. Neuropsychol Rev. 2007; 17(3):213-33. DOI: 10.1007/s11065-007-9040-z. View

Robinson A, Heaton R, Lehman R, STILSON D . The utility of the Wisconsin Card Sorting Test in detecting and localizing frontal lobe lesions. J Consult Clin Psychol. 1980; 48(5):605-14. DOI: 10.1037//0022-006x.48.5.605. View

Lie C, Specht K, Marshall J, Fink G . Using fMRI to decompose the neural processes underlying the Wisconsin Card Sorting Test. Neuroimage. 2006; 30(3):1038-49. DOI: 10.1016/j.neuroimage.2005.10.031. View

BERG E . A simple objective technique for measuring flexibility in thinking. J Gen Psychol. 1948; 39:15-22. DOI: 10.1080/00221309.1948.9918159. View

Lenartowicz A, Verbruggen F, Logan G, Poldrack R . Inhibition-related activation in the right inferior frontal gyrus in the absence of inhibitory cues. J Cogn Neurosci. 2011; 23(11):3388-99. DOI: 10.1162/jocn_a_00031. View

Glascher J, Rudrauf D, Colom R, Paul L, Tranel D, Damasio H . Distributed neural system for general intelligence revealed by lesion mapping. Proc Natl Acad Sci U S A. 2010; 107(10):4705-9. PMC: 2842050. DOI: 10.1073/pnas.0910397107. View

Bishara A, Kruschke J, Stout J, Bechara A, McCabe D, Busemeyer J . Sequential Learning Models for the Wisconsin Card Sort Task: Assessing Processes in Substance Dependent Individuals. J Math Psychol. 2010; 54(1):5-13. PMC: 2872109. DOI: 10.1016/j.jmp.2008.10.002. View

10.

Montague P, Dolan R, Friston K, Dayan P . Computational psychiatry. Trends Cogn Sci. 2011; 16(1):72-80. PMC: 3556822. DOI: 10.1016/j.tics.2011.11.018. View

11.

Bates E, Wilson S, Saygin A, Dick F, Sereno M, Knight R . Voxel-based lesion-symptom mapping. Nat Neurosci. 2003; 6(5):448-50. DOI: 10.1038/nn1050. View

12.

Adolphs R . Human Lesion Studies in the 21st Century. Neuron. 2016; 90(6):1151-1153. PMC: 5656290. DOI: 10.1016/j.neuron.2016.05.014. View

13.

Jodzio K, Biechowska D . Wisconsin card sorting test as a measure of executive function impairments in stroke patients. Appl Neuropsychol. 2010; 17(4):267-77. DOI: 10.1080/09084282.2010.525104. View

14.

Hampshire A, Chamberlain S, Monti M, Duncan J, Owen A . The role of the right inferior frontal gyrus: inhibition and attentional control. Neuroimage. 2010; 50(3):1313-9. PMC: 2845804. DOI: 10.1016/j.neuroimage.2009.12.109. View

15.

Grafman J, Jonas B, Salazar A . Wisconsin Card Sorting Test performance based on location and size of neuroanatomical lesion in Vietnam veterans with penetrating head injury. Percept Mot Skills. 1990; 71(3 Pt 2):1120-2. DOI: 10.2466/pms.1990.71.3f.1120. View

16.

Sutterer M, Bruss J, Boes A, Voss M, Bechara A, Tranel D . Canceled connections: Lesion-derived network mapping helps explain differences in performance on a complex decision-making task. Cortex. 2016; 78:31-43. PMC: 4854765. DOI: 10.1016/j.cortex.2016.02.002. View

17.

Goldstein B, Obrzut J, John C, Ledakis G, Armstrong C . The impact of frontal and non-frontal brain tumor lesions on Wisconsin Card Sorting Test performance. Brain Cogn. 2004; 54(2):110-6. DOI: 10.1016/S0278-2626(03)00269-0. View

18.

Rorden C, Karnath H, Bonilha L . Improving lesion-symptom mapping. J Cogn Neurosci. 2007; 19(7):1081-8. DOI: 10.1162/jocn.2007.19.7.1081. View

19.

Glascher J, Adolphs R, Damasio H, Bechara A, Rudrauf D, Calamia M . Lesion mapping of cognitive control and value-based decision making in the prefrontal cortex. Proc Natl Acad Sci U S A. 2012; 109(36):14681-6. PMC: 3437894. DOI: 10.1073/pnas.1206608109. View

20.

Sutterer M, Tranel D . Neuropsychology and cognitive neuroscience in the fMRI era: A recapitulation of localizationist and connectionist views. Neuropsychology. 2017; 31(8):972-980. PMC: 5788719. DOI: 10.1037/neu0000408. View