Current Status of Stem Cell Treatment for Type I Diabetes Mellitus

Overview

Journal Tissue Eng Regen Med

Date 2019 Jan 4

PMID 30603589

Citations 3

Authors

Anupama Kakkar

Ashima Sorout

Mahak Tiwari

Pallavi Shrivastava

Poonam Meena

Sumit Kumar Saraswat

Supriya Srivastava

Rajan Datt

Siddharth Pandey

Affiliations

Soon will be listed here.

Abstract

Background: Diabetes mellitus is a major health concern in current scenario which has been found to affect people of almost all ages. The disease has huge impact on global health; therefore, alternate methods apart from insulin injection are being explored to cure diabetes. Therefore, this review mainly focuses on the current status and therapeutic potential of stem cells mainly mesenchymal stem cells (MSCs) for Type 1 diabetes mellitus in preclinical animal models as well as humans.

Methods: Current treatment for Type 1 diabetes mellitus mainly includes use of insulin which has its own limitations and also the underlying mechanism of diseases is still not explored. Therefore, alternate methods to cure diabetes are being explored. Stem cells are being investigated as an alternative therapy for treatment of various diseases including diabetes. Few preclinical studies have also been conducted using undifferentiated MSCs as well as MSCs differentiated into β islet cells.

Results: These stem cell transplant studies have highlighted the benefits of MSCs, which have shown promising results. Few human trials using stem cells have also affirmed the potential of these cells in alleviating the symptoms.

Conclusion: Stem cell transplantation may prove to be a safe and effective treatment for patients with Type 1 diabetes mellitus.

Citing Articles

Functional maturation of immature β cells: A roadblock for stem cell therapy for type 1 diabetes.

Sun Z, Yu T, Jiang F, Wang W World J Stem Cells. 2021; 13(3):193-207.

PMID: 33815669 PMC: 8006013. DOI: 10.4252/wjsc.v13.i3.193.

Bifunctional Labeling of Rabbit Mesenchymal Stem Cells for MR Imaging and Fluorescence Microscopy.

Berninger M, Rodriguez-Gonzalez P, Schilling F, Haller B, Lichtenstein T, Imhoff A Mol Imaging Biol. 2019; 22(2):303-312.

PMID: 31209781 DOI: 10.1007/s11307-019-01385-8.

Tissue Regeneration of Human Mesenchymal Stem Cells on Porous Gelatin Micro-Carriers by Long-Term Dynamic Culture.

Nguyen L, Bang S, Noh I Tissue Eng Regen Med. 2019; 16(1):19-28.

PMID: 30815347 PMC: 6361098. DOI: 10.1007/s13770-018-00174-8.

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