Mesenchymal Stem Cell-Based Therapies Against Podocyte Damage in Diabetic Nephropathy

Overview

Journal Tissue Eng Regen Med

Date 2019 Jan 4

PMID 30603477

Citations 17

Authors

Manizheh Khalilpourfarshbafi

Fatemeh Hajiaghaalipour

Kesavanarayanan Krishnan Selvarajan

Aishah Adam

Affiliations

Soon will be listed here.

Abstract

Injury to podocytes is an early event in diabetic nephropathy leading to proteinuria with possible progression to end-stage renal failure. The podocytes are unique and highly specialized cells that cover the outer layer of kidney ultra-filtration barrier and play an important role in glomerular function. In the past few decades, adult stem cells, such as mesenchymal stem cells (MSCs) with a regenerative and differentiative capacity have been extensively used in cell-based therapies. In addition to their capability for regeneration and differentiation, MSCs contributes to their by paracrine action of a series of growth factors antiapoptotic, mitogenic and other cytokine actions that actively participate in treatment of podocyte damage through prevention of podocyte effacement, detachment and apoptosis. It is hoped that novel stem cell-based therapies will be developed in the future to prevent podocyte injury, thereby reducing the burden of kidney disease.

Citing Articles

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