A Computational Model of Ureteral Peristalsis and an Investigation into Ureteral Reflux

Overview

Journal Biomed Eng Lett

Specialty Biomedical Engineering

Date 2019 Jan 4

PMID 30603196

Citations 2

Authors

G Hosseini

C Ji

D Xu

M A Rezaienia

E Avital

A Munjiza

J J R Williams

J S A Green

Affiliations

Soon will be listed here.

Abstract

The aim of this study is to create a computational model of the human ureteral system that accurately replicates the peristaltic movement of the ureter for a variety of physiological and pathological functions. The objectives of this research are met using our in-house fluid-structural dynamics code (CgLes-Y code). A realistic peristaltic motion of the ureter is modelled using a novel piecewise linear force model. The urodynamic responses are investigated under two conditions of a healthy and a depressed contraction force. A ureteral pressure during the contraction shows a very good agreement with corresponding clinical data. The results also show a dependency of the wall shear stresses on the contraction velocity and it confirms the presence of a high shear stress at the proximal part of the ureter. Additionally, it is shown that an inefficient lumen contraction can increase the possibility of a continuous reflux during the propagation of peristalsis.

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