Hypoxia Imaging in Upper Gastrointestinal Tumors and Application to Radiation Therapy

Overview

Journal J Gastrointest Oncol

Date 2019 Jan 4

PMID 30603123

Citations 3

Authors

Randa Tao

Bryan Ager

Shane Lloyd

Anna Torgeson

Michelle Denney

David Gaffney

Jordan Kharofa

Steven H Lin

Albert C Koong

Yoshimi Anzai

John M Hoffman

Affiliations

Soon will be listed here.

Abstract

Survival for upper gastrointestinal tumors remains poor, likely in part due to treatment resistance associated with intratumoral hypoxia. In this review, we highlight advances in nuclear medicine imaging that allow for characterization of in vivo tumor hypoxia in esophageal, pancreatic, and liver cancers. Strategies for adaptive radiotherapy in upper gastrointestinal tumors are proposed that would apply information gained through hypoxia imaging to the creation of personalized radiotherapy treatment plans able to overcome hypoxia-induced treatment resistance, minimize treatment-related toxicities, and improve patient outcomes.

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