Molecular Virology of Chikungunya Virus

Overview

Journal Curr Top Microbiol Immunol

Specialties Allergy & Immunology
Microbiology

Date 2019 Jan 2

PMID 30599050

Citations 14

Authors

I Frolov

E I Frolova

Affiliations

Soon will be listed here.

Abstract

Chikungunya virus (CHIKV) was discovered more than six decades ago, but has remained poorly investigated. However, after a recent outbreak of CHIK fever in both hemispheres and viral adaptation to new species of mosquitoes, it has attracted a lot of attention. The currently available experimental data suggest that molecular mechanisms of CHIKV replication in vertebrate and mosquito cells are similar to those of other New and Old World alphaviruses. However, this virus exhibits a number of unique characteristics that distinguish it from the other, better studied members of the alphavirus genus. This review is an attempt to summarize the data accumulated thus far regarding the molecular mechanisms of alphavirus RNA replication and interaction with host cells. Emphasis was placed on demonstrating the distinct features of CHIKV in utilizing host factors to build replication complexes and modify the intracellular environment for efficient viral replication and inhibition of the innate immune response. The available data suggest that our knowledge about alphavirus replication contains numerous gaps that potentially hamper the development of new therapeutic means against CHIKV and other pathogenic alphaviruses.

Citing Articles

Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infection.

Sharma K, Subramani C, Ganesh K, Sharma A, Basu B, Balyan S PLoS Pathog. 2025; 20(12):e1012816.

PMID: 39775571 PMC: 11723598. DOI: 10.1371/journal.ppat.1012816.

Pathogenicity and virulence of chikungunya virus.

Freppel W, Silva L, Stapleford K, Herrero L Virulence. 2024; 15(1):2396484.

PMID: 39193780 PMC: 11370967. DOI: 10.1080/21505594.2024.2396484.

Advances in the Development of Non-Structural Protein 1 (NsP1) Inhibitors for the Treatment of Chikungunya Virus Infection.

Delgado-Maldonado T, Moreno-Herrera A, Rivera G Mini Rev Med Chem. 2024; 24(22):1972-1982.

PMID: 38910486 DOI: 10.2174/0113895575301735240607055839.

4'-Fluorouridine inhibits alphavirus replication and infection and .

Yin P, May N, Lello L, Fayed A, Parks M, Drobish A mBio. 2024; 15(6):e0042024.

PMID: 38700353 PMC: 11237586. DOI: 10.1128/mbio.00420-24.

Molecular characterization of Chikungunya virus recovered from patients in the Maranhão state, Brazil.

Junior A, de Melo B, Costa A, de Jesus Ferreira Costa D, Castro E, de Jesus Gomes Turri R Mol Biol Rep. 2024; 51(1):375.

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