Novel Insights into the Role of Aberrantly Expressed MNX1 (HLXB9) in Infant Acute Myeloid Leukemia

Overview

Journal Haematologica

Specialty Hematology

Date 2019 Jan 2

PMID 30598492

Citations 6

Authors

Juerg Schwaller

Affiliations

Soon will be listed here.

Citing Articles

Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13).

Weichenhan D, Riedel A, Sollier E, Toprak U, Hey J, Breuer K Blood Adv. 2024; 8(19):5100-5111.

PMID: 39121370 PMC: 11460460. DOI: 10.1182/bloodadvances.2023012161.

MNX1 Promotes Anti-HER2 Therapy Sensitivity via Transcriptional Regulation of CD-M6PR in HER2-Positive Breast Cancer.

Chi W, Xiu B, Xiong M, Wang X, Li P, Zhang Q Int J Mol Sci. 2024; 25(1).

PMID: 38203393 PMC: 10778903. DOI: 10.3390/ijms25010221.

Mechanisms associated with t(7;12) acute myeloid leukaemia: from genetics to potential treatment targets.

Ragusa D, Dijkhuis L, Pina C, Tosi S Biosci Rep. 2023; 43(1).

PMID: 36622782 PMC: 9894016. DOI: 10.1042/BSR20220489.

Engineered model of t(7;12)(q36;p13) AML recapitulates patient-specific features and gene expression profiles.

Ragusa D, Ciciro Y, Federico C, Saccone S, Bruno F, Saeedi R Oncogenesis. 2022; 11(1):50.

PMID: 36057683 PMC: 9440899. DOI: 10.1038/s41389-022-00426-2.

Infant Acute Myeloid Leukemia: A Unique Clinical and Biological Entity.

Calvo C, Fenneteau O, Leverger G, Petit A, Baruchel A, Mechinaud F Cancers (Basel). 2021; 13(4).

PMID: 33668444 PMC: 7918235. DOI: 10.3390/cancers13040777.

References

Ross A, Wang Y, Hagan D, Scherer S, Lynch S, Lindsay S . A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis. Nat Genet. 1998; 20(4):358-61. DOI: 10.1038/3828. View

Dastugue N, Lafage-Pochitaloff M, Pages M, Radford I, Bastard C, Talmant P . Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Français de Cytogénétique Hématologique (GFCH). Blood. 2002; 100(2):618-26. DOI: 10.1182/blood-2001-12-0241. View

Thaler J, Harrison K, Sharma K, Lettieri K, Kehrl J, Pfaff S . Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9. Neuron. 1999; 23(4):675-87. DOI: 10.1016/s0896-6273(01)80027-1. View

Beverloo H, Panagopoulos I, Isaksson M, van Wering E, van Drunen E, de Klein A . Fusion of the homeobox gene HLXB9 and the ETV6 gene in infant acute myeloid leukemias with the t(7;12)(q36;p13). Cancer Res. 2001; 61(14):5374-7. View

Ingenhag D, Reister S, Auer F, Bhatia S, Wildenhain S, Picard D . The homeobox transcription factor HB9 induces senescence and blocks differentiation in hematopoietic stem and progenitor cells. Haematologica. 2018; 104(1):35-46. PMC: 6312034. DOI: 10.3324/haematol.2018.189407. View

Li H, Arber S, Jessell T, Edlund H . Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat Genet. 1999; 23(1):67-70. DOI: 10.1038/12669. View

Desai S, Modali S, Parekh V, Kebebew E, Agarwal S . GSK-3β protein phosphorylates and stabilizes HLXB9 protein in insulinoma cells to form a targetable mechanism of controlling insulinoma cell proliferation. J Biol Chem. 2014; 289(9):5386-98. PMC: 3937616. DOI: 10.1074/jbc.M113.533612. View

Bolouri H, Farrar J, Triche Jr T, Ries R, Lim E, Alonzo T . The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions. Nat Med. 2017; 24(1):103-112. PMC: 5907936. DOI: 10.1038/nm.4439. View

Nagel S, Kaufmann M, Scherr M, Drexler H, MacLeod R . Activation of HLXB9 by juxtaposition with MYB via formation of t(6;7)(q23;q36) in an AML-M4 cell line (GDM-1). Genes Chromosomes Cancer. 2004; 42(2):170-8. DOI: 10.1002/gcc.20113. View

10.

Wildenhain S, Ingenhag D, Ruckert C, Degistirici O, Dugas M, Meisel R . Homeobox protein HB9 binds to the prostaglandin E receptor 2 promoter and inhibits intracellular cAMP mobilization in leukemic cells. J Biol Chem. 2012; 287(48):40703-12. PMC: 3504783. DOI: 10.1074/jbc.M111.308965. View

11.

Ballabio E, Cantarella C, Federico C, Di Mare P, Hall G, Harbott J . Ectopic expression of the HLXB9 gene is associated with an altered nuclear position in t(7;12) leukaemias. Leukemia. 2009; 23(6):1179-82. DOI: 10.1038/leu.2009.15. View

12.

Harrison K, Thaler J, Pfaff S, Gu H, Kehrl J . Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nat Genet. 1999; 23(1):71-5. DOI: 10.1038/12674. View

13.

Espersen A, Noren-Nystrom U, Abrahamsson J, Ha S, Pronk C, Jahnukainen K . Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is associated with infancy and trisomy 19: Data from Nordic Society for Pediatric Hematology and Oncology (NOPHO-AML) and review of the literature. Genes Chromosomes Cancer. 2018; 57(7):359-365. DOI: 10.1002/gcc.22538. View

14.

Wildenhain S, Ruckert C, Rottgers S, Harbott J, Ludwig W, Schuster F . Expression of cell-cell interacting genes distinguishes HLXB9/TEL from MLL-positive childhood acute myeloid leukemia. Leukemia. 2010; 24(9):1657-60. DOI: 10.1038/leu.2010.146. View

15.

Tosi S, Harbott J, Teigler-Schlegel A, Haas O, Pirc-Danoewinata H, Harrison C . t(7;12)(q36;p13), a new recurrent translocation involving ETV6 in infant leukemia. Genes Chromosomes Cancer. 2000; 29(4):325-32. DOI: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1039>3.0.co;2-9. View

16.

Slater R, von Drunen E, Kroes W, Weghuis D, van den Berg E, Smit E . t(7;12)(q36;p13) and t(7;12)(q32;p13)--translocations involving ETV6 in children 18 months of age or younger with myeloid disorders. Leukemia. 2001; 15(6):915-20. DOI: 10.1038/sj.leu.2402121. View

17.

von Bergh A, van Drunen E, van Wering E, van Zutven L, Hainmann I, Lonnerholm G . High incidence of t(7;12)(q36;p13) in infant AML but not in infant ALL, with a dismal outcome and ectopic expression of HLXB9. Genes Chromosomes Cancer. 2006; 45(8):731-9. DOI: 10.1002/gcc.20335. View

18.

Johansson B, Billstrom R, Mauritzson N, Mitelman F . Trisomy 19 as the sole chromosomal anomaly in hematologic neoplasms. Cancer Genet Cytogenet. 1994; 74(1):62-5. DOI: 10.1016/0165-4608(94)90031-0. View

19.

Flanagan S, De Franco E, Lango Allen H, Zerah M, Abdul-Rasoul M, Edge J . Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man. Cell Metab. 2014; 19(1):146-54. PMC: 3887257. DOI: 10.1016/j.cmet.2013.11.021. View

20.

Dang J, Nance S, Ma J, Cheng J, Walsh M, Vogel P . AMKL chimeric transcription factors are potent inducers of leukemia. Leukemia. 2017; 31(10):2228-2234. PMC: 5791746. DOI: 10.1038/leu.2017.51. View