There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients

Overview

Journal J Diabetes Res

Publisher Wiley

Specialty Endocrinology

Date 2019 Jan 1

PMID 30596103

Citations 6

Authors

Mariana Nogueira Coutinho

Aluizio Barbosa Carvalho

Maria Aparecida Dalboni

Margaret Gori Mouro

Elisa Mieko Suemitsu Higa

Valeria Costa-Hong

Luiz Aparecido Bortolotto

Rejane Augusta de Oliveira Figueiredo

Maria Eugenia Fernandes Canziani

Affiliations

Soon will be listed here.

Abstract

Background: Patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (DM) have increased risk of endothelial dysfunction, cardiovascular disease, and mortality. Several studies have separately analyzed endothelial function in these populations. However, data of patients with both CKD and DM are scarce. The aim of this study was to evaluate whether the presence of DM has any additional effect on the endothelial dysfunction of CKD patients.

Methods: We measured endothelial progenitor cells (EPCs), stromal-derived factor 1 alpha (SDF-1), serum and urinary nitric oxide (NO), flow-mediated dilation (FMD), and pulse wave velocity (PWV) in 37 CKD patients with DM (CKD-DM group) and in 37 without DM (CKD group).

Results: CKD-DM group had a higher prevalence of obesity ( < 0.01), previous myocardial infarction ( = 0.02), myocardial revascularization ( = 0.04), and a trend for more peripheral artery disease ( = 0.07). Additionally, CKD-DM group had higher EPC ( = 0.001) and PWV ( < 0.001) values. On the other hand, no difference in SDF-1 and serum or urinary NO and FMD was observed between the groups.

Conclusions: Endothelial dysfunction is frequent in CKD patients, and an additive effect of diabetes cannot be implicated, suggesting the predominant role of uremia in this condition.

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