A STROBE Compliant Observational Study on Trace Elements in Patients with Ulcerative Colitis and Their Relationship with Disease Activity

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2018 Dec 30

PMID 30593128

Citations 9

Authors

Farid Poursadegh

Mitra Ahadi

Hassan Vosoughinia

Maryam Salehi

Ali Beheshti Namdar

Mohammad Reza Farzanehfar

Bahram Memar

Reza Ziaolhagh

Affiliations

Soon will be listed here.

Abstract

Nutritional deficiencies and malnutrition are considered to be related to ulcerative colitis (UC); however, the association between serum levels of micronutrients and UC is not well known. This study aimed to evaluate the serum levels of micronutrients in UC patients and investigate their association with disease activity.This cross-sectional study was conducted on UC patients visiting the Department of Gastroenterology at 3 different teaching hospitals between January 2016 and January 2017. UC activity was measured based on Truelove and Witts' severity index and guidelines for colonoscopy. A healthy gender- and age-matched group was also selected. Serum levels of zinc, copper, selenium, ceruloplasmin, albumin, and total protein were compared between the 2 groups of UC patients and healthy subjects using independent-samples t test. Also, the association between serum levels of micronutrients and UC activity was assessed by using Pearson and Spearman correlation coefficient tests. The data were analyzed by SPSS version 21, considering P ≤.05 as the statistical significance level.Overall, 112 (54 male and 58 female) individuals with the mean age of 34.6 years were studied in the 2 groups of UC patients (n = 56) and healthy subjects (n = 56). The 2 groups were homogeneous in terms of age, gender, marital status, place of residence, and educational level (P >.05). The serum levels of total protein (6.41 ± 1.1 vs 7.41 ± 0.4 g/dL; P = .0001), albumin (4.72 ± 1.1 vs 5.19 ± 0.28 g/dL; P = .0001), zinc (679 ± 62 vs 1055 ± 156 μg/L; P = .0001), and selenium (81.85 ± 6.4 vs 108.4 ± 12.98 micg/L; P = .0001) were significantly lower in the UC patients. The serum level of copper did not differ significantly between the 2 groups (P = .1).Considering the simultaneous reduction in nutritional criteria in the UC patient group, malnutrition appears to be a factor affecting micronutrient deficiency in patients with UC.

Citing Articles

Selenium deficiency in inflammatory bowel disease: A comprehensive meta-analysis.

Liu S, Lin T, Wang W, Jing F, Sheng J Heliyon. 2024; 10(22):e40139.

PMID: 39584095 PMC: 11583699. DOI: 10.1016/j.heliyon.2024.e40139.

The Role of Dietary Habits in the Pathogenesis and Development of Inflammatory Bowel Disease: A Narrative Review.

Ahadi M, Rouhbakhsh Zahmatkesh M, Ebrahimi P, AkbariRad M Middle East J Dig Dis. 2024; 16(1):5-11.

PMID: 39050099 PMC: 11264837. DOI: 10.34172/mejdd.2024.362.

Risk Factors of Low Bone Mineral Density in Newly Diagnosed Pediatric Inflammatory Bowel Disease.

Ahn M, Yoo I Nutrients. 2023; 15(24).

PMID: 38140307 PMC: 10746078. DOI: 10.3390/nu15245048.

Zinc Deficiency and Therapeutic Value of Zinc Supplementation in Pediatric Gastrointestinal Diseases.

Chao H Nutrients. 2023; 15(19).

PMID: 37836377 PMC: 10574543. DOI: 10.3390/nu15194093.

Nutrition, Nutritional Status, Micronutrients Deficiency, and Disease Course of Inflammatory Bowel Disease.

Valvano M, Capannolo A, Cesaro N, Stefanelli G, Fabiani S, Frassino S Nutrients. 2023; 15(17).

PMID: 37686856 PMC: 10489664. DOI: 10.3390/nu15173824.

References

Tran C, Butler R, Philcox J, Rofe A, Howarth G, Coyle P . Regional distribution of metallothionein and zinc in the mouse gut: comparison with metallothionien-null mice. Biol Trace Elem Res. 1998; 63(3):239-51. DOI: 10.1007/BF02778942. View

Tran C, Ball J, Sundar S, Coyle P, Howarth G . The role of zinc and metallothionein in the dextran sulfate sodium-induced colitis mouse model. Dig Dis Sci. 2007; 52(9):2113-21. DOI: 10.1007/s10620-007-9765-9. View

Andoh A, Hirashima M, Maeda H, Hata K, Inatomi O, Tsujikawa T . Serum selenoprotein-P levels in patients with inflammatory bowel disease. Nutrition. 2005; 21(5):574-9. DOI: 10.1016/j.nut.2004.08.025. View

Han Y, Yoon H, Lim S, Sung M, Shin C, Park Y . Risk Factors for Vitamin D, Zinc, and Selenium Deficiencies in Korean Patients with Inflammatory Bowel Disease. Gut Liver. 2017; 11(3):363-369. PMC: 5417778. DOI: 10.5009/gnl16333. View

Xia B, Deng C, Chen D, Zhou Y, Xiao J . Role of copper zinc superoxide dismutase in the short-term treatment of acetic acid-induced colitis in rats. Acta Gastroenterol Latinoam. 1996; 26(4):227-30. View

Geerling B, Stockbrugger R, Brummer R . Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls. Eur J Clin Nutr. 2000; 54(6):514-21. DOI: 10.1038/sj.ejcn.1601049. View

Skrovanek S, DiGuilio K, Bailey R, Huntington W, Urbas R, Mayilvaganan B . Zinc and gastrointestinal disease. World J Gastrointest Pathophysiol. 2014; 5(4):496-513. PMC: 4231515. DOI: 10.4291/wjgp.v5.i4.496. View

Ainley C, Cason J, Carlsson L, Slavin B, Thompson R . Zinc status in inflammatory bowel disease. Clin Sci (Lond). 1988; 75(3):277-83. DOI: 10.1042/cs0750277. View

Alfthan G, Eurola M, Ekholm P, Venalainen E, Root T, Korkalainen K . Effects of nationwide addition of selenium to fertilizers on foods, and animal and human health in Finland: From deficiency to optimal selenium status of the population. J Trace Elem Med Biol. 2014; 31:142-7. DOI: 10.1016/j.jtemb.2014.04.009. View

10.

Sturniolo G, Mestriner C, Lecis P, DOdorico A, Venturi C, Irato P . Altered plasma and mucosal concentrations of trace elements and antioxidants in active ulcerative colitis. Scand J Gastroenterol. 1998; 33(6):644-9. DOI: 10.1080/00365529850171936. View

11.

Rocha R, Santana G, Almeida N, Lyra A . Analysis of fat and muscle mass in patients with inflammatory bowel disease during remission and active phase. Br J Nutr. 2008; 101(5):676-9. DOI: 10.1017/S0007114508032224. View

12.

Castro Aguilar-Tablada T, Navarro-Alarcon M, Quesada Granados J, Samaniego Sanchez C, Rufian-Henares J, Nogueras-Lopez F . Ulcerative Colitis and Crohn's Disease Are Associated with Decreased Serum Selenium Concentrations and Increased Cardiovascular Risk. Nutrients. 2016; 8(12). PMC: 5188435. DOI: 10.3390/nu8120780. View

13.

VAN PATTER W, BARGEN J, DOCKERTY M, FELDMAN W, MAYO C, WAUGH J . Regional enteritis. Gastroenterology. 1954; 26(3):347-450. View

14.

Fernandez-Banares F, Mingorance M, Esteve M, Cabre E, Lachica M, Abad-Lacruz A . Serum zinc, copper, and selenium levels in inflammatory bowel disease: effect of total enteral nutrition on trace element status. Am J Gastroenterol. 1990; 85(12):1584-9. View

15.

Di Leo V, DInca R, Barollo M, Tropea A, Fries W, Mazzon E . Effect of zinc supplementation on trace elements and intestinal metallothionein concentrations in experimental colitis in the rat. Dig Liver Dis. 2001; 33(2):135-9. DOI: 10.1016/s1590-8658(01)80068-2. View

16.

Siva S, Rubin D, Gulotta G, Wroblewski K, Pekow J . Zinc Deficiency is Associated with Poor Clinical Outcomes in Patients with Inflammatory Bowel Disease. Inflamm Bowel Dis. 2016; 23(1):152-157. PMC: 5177471. DOI: 10.1097/MIB.0000000000000989. View

17.

Mohammadi E, Qujeq D, Taheri H, Hajian-Tilaki K . Evaluation of Serum Trace Element Levels and Superoxide Dismutase Activity in Patients with Inflammatory Bowel Disease: Translating Basic Research into Clinical Application. Biol Trace Elem Res. 2016; 177(2):235-240. DOI: 10.1007/s12011-016-0891-0. View

18.

Takaoka A, Sasaki M, Kurihara M, Iwakawa H, Inoue M, Bamba S . Comparison of energy metabolism and nutritional status of hospitalized patients with Crohn's disease and those with ulcerative colitis. J Clin Biochem Nutr. 2015; 56(3):208-14. PMC: 4454083. DOI: 10.3164/jcbn.14-95. View

19.

Luk H, Ko J, Fung H, Cho C . Delineation of the protective action of zinc sulfate on ulcerative colitis in rats. Eur J Pharmacol. 2002; 443(1-3):197-204. DOI: 10.1016/s0014-2999(02)01592-3. View

20.

Lanfranchi G, Brignola C, Campieri M, Bazzocchi G, Pasquali R, Bassein L . Assessment of nutritional status in Crohn's disease in remission or low activity. Hepatogastroenterology. 1984; 31(3):129-32. View