Comprehensive Lung Function Assessment Does Not Allow to Infer Response to Pulmonary Rehabilitation in Patients with COPD

Overview

Journal J Clin Med

Specialty General Medicine

Date 2018 Dec 29

PMID 30591662

Citations 9

Authors

Ingrid M L Augustin

Emiel F M Wouters

Sarah Houben-Wilke

Swetlana Gaffron

Daisy J A Janssen

Frits M E Franssen

Martijn A Spruit

Affiliations

Soon will be listed here.

Abstract

The degree of lung function is frequently used as referral criterion for pulmonary rehabilitation. The efficacy of pulmonary rehabilitation was assessed in 518 chronic obstructive pulmonary disease (COPD) patients, after clustering based on a comprehensive pre-rehabilitation lung function assessment. Mean improvements in dyspnea, exercise performance, health status, mood status and problematic activities of daily life after pulmonary rehabilitation were mostly comparable between the seven clusters, despite significant differences in the degree of lung function. The current study demonstrates no significant relationship between the seven lung-function-based clusters and response to pulmonary rehabilitation. Therefore, baseline lung function cannot be used to identify those who will respond well to pulmonary rehabilitation, and moreover, cannot be used as a criterion for referral to pulmonary rehabilitation in patients with COPD.

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References

Vogiatzis I, Williamson A, Miles J, TAYLOR I . Physiological response to moderate exercise workloads in a pulmonary rehabilitation program in patients with varying degrees of airflow obstruction. Chest. 1999; 116(5):1200-7. DOI: 10.1378/chest.116.5.1200. View

Wilson T, Holt T, Greenhalgh T . Complexity science: complexity and clinical care. BMJ. 2001; 323(7314):685-8. PMC: 1121241. DOI: 10.1136/bmj.323.7314.685. View

Jones P . Interpreting thresholds for a clinically significant change in health status in asthma and COPD. Eur Respir J. 2002; 19(3):398-404. DOI: 10.1183/09031936.02.00063702. View

de Torres J, Pinto-Plata V, Ingenito E, Bagley P, Gray A, Berger R . Power of outcome measurements to detect clinically significant changes in pulmonary rehabilitation of patients with COPD. Chest. 2002; 121(4):1092-8. DOI: 10.1378/chest.121.4.1092. View

Laviolette L, Bourbeau J, Bernard S, Lacasse Y, Pepin V, Breton M . Assessing the impact of pulmonary rehabilitation on functional status in COPD. Thorax. 2007; 63(2):115-21. DOI: 10.1136/thx.2006.076844. View

Puhan M, Frey M, Buchi S, Schunemann H . The minimal important difference of the hospital anxiety and depression scale in patients with chronic obstructive pulmonary disease. Health Qual Life Outcomes. 2008; 6:46. PMC: 2459149. DOI: 10.1186/1477-7525-6-46. View

Spruit M, Watkins M, Edwards L, Vestbo J, Calverley P, Pinto-Plata V . Determinants of poor 6-min walking distance in patients with COPD: the ECLIPSE cohort. Respir Med. 2010; 104(6):849-57. DOI: 10.1016/j.rmed.2009.12.007. View

Agusti A, Calverley P, Celli B, Coxson H, Edwards L, Lomas D . Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res. 2010; 11:122. PMC: 2944278. DOI: 10.1186/1465-9921-11-122. View

Annegarn J, Meijer K, Passos V, Stute K, Wiechert J, Savelberg H . Problematic activities of daily life are weakly associated with clinical characteristics in COPD. J Am Med Dir Assoc. 2011; 13(3):284-90. DOI: 10.1016/j.jamda.2011.01.002. View

10.

Tsiligianni I, Kocks J, Tzanakis N, Siafakas N, van der Molen T . Factors that influence disease-specific quality of life or health status in patients with COPD: a review and meta-analysis of Pearson correlations. Prim Care Respir J. 2011; 20(3):257-68. PMC: 6549844. DOI: 10.4104/pcrj.2011.00029. View

11.

Vogiatzis I, Terzis G, Stratakos G, Cherouveim E, Athanasopoulos D, Spetsioti S . Effect of pulmonary rehabilitation on peripheral muscle fiber remodeling in patients with COPD in GOLD stages II to IV. Chest. 2011; 140(3):744-752. DOI: 10.1378/chest.10-3058. View

12.

Huber M, Knottnerus J, Green L, van der Horst H, Jadad A, Kromhout D . How should we define health?. BMJ. 2011; 343:d4163. DOI: 10.1136/bmj.d4163. View

13.

Spruit M, Singh S, Garvey C, ZuWallack R, Nici L, Rochester C . An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med. 2013; 188(8):e13-64. DOI: 10.1164/rccm.201309-1634ST. View

14.

Holland A, Spruit M, Troosters T, Puhan M, Pepin V, Saey D . An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease. Eur Respir J. 2014; 44(6):1428-46. DOI: 10.1183/09031936.00150314. View

15.

Singh S, Puhan M, Andrianopoulos V, Hernandes N, Mitchell K, Hill C . An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease. Eur Respir J. 2014; 44(6):1447-78. DOI: 10.1183/09031936.00150414. View

16.

McCarthy B, Casey D, Devane D, Murphy K, Murphy E, Lacasse Y . Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2015; (2):CD003793. PMC: 10008021. DOI: 10.1002/14651858.CD003793.pub3. View

17.

Ziegelstein R . Personomics. JAMA Intern Med. 2015; 175(6):888-9. DOI: 10.1001/jamainternmed.2015.0861. View

18.

Smid D, Wilke S, Jones P, Muris J, Wouters E, Franssen F . Impact of cardiovascular comorbidities on COPD Assessment Test (CAT) and its responsiveness to pulmonary rehabilitation in patients with moderate to very severe COPD: protocol of the Chance study. BMJ Open. 2015; 5(7):e007536. PMC: 4513521. DOI: 10.1136/bmjopen-2014-007536. View

19.

Spruit M, Augustin I, Vanfleteren L, Janssen D, Gaffron S, Pennings H . Differential response to pulmonary rehabilitation in COPD: multidimensional profiling. Eur Respir J. 2015; 46(6):1625-35. DOI: 10.1183/13993003.00350-2015. View

20.

Vanfleteren M, Koopman M, Spruit M, Pennings H, Smeenk F, Pieters W . Effectiveness of Pulmonary Rehabilitation in Patients With Chronic Obstructive Pulmonary Disease With Different Degrees of Static Lung Hyperinflation. Arch Phys Med Rehabil. 2018; 99(11):2279-2286.e3. DOI: 10.1016/j.apmr.2018.05.011. View