The Association Between Preeclampsia and Autism Spectrum Disorders Among Children: a Meta-analysis

Overview

Journal Korean J Pediatr

Specialty Pediatrics

Date 2018 Dec 28

PMID 30590001

Citations 20

Authors

Ensiyeh Jenabi

Manoochehr Karami

Salman Khazaei

Saeid Bashirian

Affiliations

Soon will be listed here.

Abstract

Purpose: This meta-analysis pooled relevant case-control and cohort studies to evaluate the association between preeclampsia and the risk of autism spectrum disorders (ASDs) in children.

Methods: The search for relevant studies in major databases was performed, which included Web of Science, PubMed, and Scopus up to May 2018. The odds ratios (ORs) or rate ratios (RRs) with 95% confidence intervals (CIs) were extracted from eligible studies to determine the association among the studies.

Results: The pooled estimates of ORs and RRs indicated a significant association between preeclampsia and ASD (OR, 1.36; 95% CI, 1.12-1.60) and (RR, 1.30; 95% CI, 1.20-1.41).

Conclusions: Despite existing controversy, our findings indicated that preeclampsia was associated with an increased risk of ASD among children.

Citing Articles

Pre and perinatal predictors on autism spectrum disorders: a case-control study in the west of Iran.

Jenabi E, Salehi A, Ayubi E, Seyedi M, Khazaei S, Jourmand H Matern Health Neonatol Perinatol. 2024; 10(1):13.

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Neurodevelopmental Disruptions in Children of Preeclamptic Mothers: Pathophysiological Mechanisms and Consequences.

Gonzalez-Rojas A, Valencia-Narbona M Int J Mol Sci. 2024; 25(7).

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Modulation of vagal activity may help reduce neurodevelopmental damage in the offspring of mothers with pre-eclampsia.

Abarca-Castro E, Talavera-Pena A, Reyes-Lagos J, Becerril-Villanueva E, Perez-Sanchez G, de la Pena F Front Immunol. 2023; 14:1280334.

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Maternal Inflammation with Elevated Kynurenine Metabolites Is Related to the Risk of Abnormal Brain Development and Behavioral Changes in Autism Spectrum Disorder.

Murakami Y, Imamura Y, Kasahara Y, Yoshida C, Momono Y, Fang K Cells. 2023; 12(7).

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