The Relation of Serum Prolactin Levels and Infection in Humans

Overview

Journal Int J Gen Med

Publisher Dove Medical Press

Specialty General Medicine

Date 2018 Dec 28

PMID 30588064

Citations 5

Authors

A Mohammadpour

H Keshavarz

M Mohebali

M Salimi

A Teimouri

S Shojaee

Affiliations

Soon will be listed here.

Abstract

Background: is an intracellular protozoan parasite distributed worldwide. Although the infection is benign in immunocompetent individuals, it is life threatening and complicated in immunocompromised patients and fetuses of pregnant women who received their first exposure to during the pregnancy. Prolactin (PRL) is a hormone that is secreted by the pituitary gland, and it is confirmed that it plays a role in the immune system. The present study was carried out to assess the possible relation between serum PRL levels and infection frequency in human.

Methods: In this cross-sectional study, 343 serum samples (240 from women and 103 from men) were collected from individuals who were referred for PRL checking in laboratories of Karaj, Iran. Blood samples were collected, and sera were separated and analyzed for the detection of anti- IgG antibody by ELISA method. The levels of PRL were measured by Roche Elecsys 2010 analyzer, electrochemiluminescence technology.

Results: Of 343 sera, 110 samples (32%) consisting of samples from 42 men and 68 women had anti- IgG antibody. The prevalence of infection in women with high PRL levels was lower than that in the comparison group with normal levels of PRL and the relationship between these two parameters was statistically significant (=0.016). In women with hyperprolactinemia, by increasing of PRL levels, the prevalence of infection was reduced.

Conclusion: The results of the current study confirmed the previous studies based on immunoregulatory role of PRL and indicated that high levels of PRL could be related to seronegativity in women.

Citing Articles

Follow-Up Study of 17-β Estradiol, Prolactin and Progesterone with the Kinetics and Prevalence of Infection in Pregnant Women.

Luna Rojas Y, Camarena Pulido E, Rodriguez-Perez L, Galvan-Ramirez M Curr Issues Mol Biol. 2024; 46(6):5701-5711.

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Trypanosoma cruzi Isolates Naturally Adapted to Congenital Transmission Display a Unique Strategy of Transplacental Passage.

Faral-Tello P, Greif G, Romero S, Cabrera A, Oviedo C, Gonzalez T Microbiol Spectr. 2023; :e0250422.

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Recombinant Mouse Prolactin Confers Partial Protection Against Toxoplasma gondii Infection in a Pre-treated Experimental Murine Model.

Atia A, Beshay E, Fath-Allah S, Sweed D, El-Refai S Acta Parasitol. 2022; 68(1):182-193.

PMID: 36542295 DOI: 10.1007/s11686-022-00651-0.

The Role of Chicken Prolactin, Growth Hormone and Their Receptors in the Immune System.

Mo G, Hu B, Wei P, Luo Q, Zhang X Front Microbiol. 2022; 13:900041.

PMID: 35910654 PMC: 9331192. DOI: 10.3389/fmicb.2022.900041.

Assessment of an In-House Enzyme-Linked Immunosorbent Assay and IgG Avidity Test Based on SAG1 and GRA7 Proteins for Discriminating between Acute and Chronic Toxoplasmosis in Humans.

Teimouri A, Abbaszadeh Afshar M, Mohtasebi S, Azami S, Alimi R, Keshavarz H J Clin Microbiol. 2021; 59(8):e0041621.

PMID: 34077255 PMC: 8288279. DOI: 10.1128/JCM.00416-21.

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