Metabolic and Morphometric Changes in Indonesian Cynomolgus Monkeys (Macaca Fascicularis) Fed an Atherogenic Diet Composed of Locally Sourced Ingredients

Overview

Journal Vet World

Specialty Veterinary Medicine

Date 2018 Dec 28

PMID 30587897

Citations 3

Authors

Sri Rahmatul Laila

Dewi Apri Astuti

Irma Herawati Suparto

Ekowati Handharyani

Dondin Sajuthi

Affiliations

Soon will be listed here.

Abstract

Background And Aim: This study was designed to determine the effects of a new atherogenic diet formulated at Institut Pertanian Bogor (IPB) (Bogor, Indonesia) on metabolic, morphometric, and carotid artery imaging of cynomolgus monkeys.

Materials And Methods: A total of 20 adult male cynomolgus monkeys fed IPB-1 atherogenic diet for 1 year. Total plasma cholesterol (TPC), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, and morphometric measurements were evaluated at baseline and monthly during the study. Carotid plaques and intima-media thickness (IMT) were measured using ultrasonography at baseline and after 8 months of treatment.

Results: This diet increased TPC, LDL, and TPC/HDL ratio and induced carotid atherosclerosis in this model. The TPC, LDL, and TPC/HDL ratio were positively associated; however, HDL was negatively associated with carotid plaques and IMT.

Conclusion: The IPB-1 atherogenic diet formulated with locally and readily available ingredients provides an economically and scientifically feasible monkey model to study atherosclerosis in Indonesia and Southeast Asia.

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Atherosclerotic Lesion of the Carotid Artery in Indonesian Cynomolgus Monkeys Receiving a Locally Sourced Atherogenic Diet.

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