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Changes in Incidence and Prevalence of Human Papillomavirus in Tonsillar and Base of Tongue Cancer During 2000-2016 in the Stockholm Region and Sweden

Abstract

Background: Tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC) has increased. In Stockholm, the proportion of human papillomavirus (HPV)-positive cases and the incidence of TSCC rose between 1970 and 2006 then stabilized. Here, HPV-prevalence, and TSCC/BOTSCC incidence 2000-2016, in Stockholm and Sweden were followed.

Methods: Incidence data for 2000-2016 were obtained from the Swedish Cancer Registry. TSCC/BOTSCC biopsies, 2013-2016 from Stockholm, were examined for HPV DNA and p16 , or data obtained from medical reports. For cases 2000-2012, data were available from previous studies.

Results: The incidence of TSCC/BOTSCC has continued to rise in Stockholm and Sweden 2000-2016, especially after 2008. HPV DNA and p16 analysis was determined for 795 Stockholm cases from 2000 to 2016, with 72% being HPV DNA and p16 positive 2013-2016, and 70% positive 2000-2016.

Conclusion: During 2000-2016, especially after 2008, the incidence of TSCC/BOTSCC has continued to increase in Stockholm and Sweden, with an HPV-prevalence of approximately 70% in Stockholm.

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