Ameliorative Effects of Helianthus Annuus Against Nephrotoxic, Cardiac, and Haematological Disorders in Alloxan-induced Hyperglycaemia in Albino Rats

Overview

Journal J Vet Res

Publisher Sciendo

Specialty Veterinary Medicine

Date 2018 Dec 26

PMID 30584619

Citations 1

Authors

Samuel Okwudili Onoja

Samuel Chukwuneke Udem

Aruh Ottah Anaga

Affiliations

Soon will be listed here.

Abstract

Introduction: The study evaluated the ameliorative effects of leaf extract on nephrotoxicity, cardiac, and haematologic disorders in alloxan-induced hyperglycaemic rats.

Material And Methods: The cold maceration method with 80% methanol was used in the preparation of . extract. Thirty alloxan-induced hyperglycaemic rats were randomly assigned to five equal groups (A-E). Groups A and B received 5% tween-20 solution in water (5 mL/kg) and glibenclamide (2 mg/kg), respectively; while groups C, D, and E received 150, 300, and 600 mg/kg of the extract, respectively, once daily for 21 consecutive days. The levels of serum urea, creatinine, haematological indices, and histopathological changes in the kidneys and heart were evaluated 24 h after the last treatment on day 21.

Results: The extract and glibenclamide significantly (P < 0.05) reduced the levels of serum urea and urea : creatinine ratio in diabetic rats when compared with the vehicle treated group. The extract and glibenclamide also ameliorated haematological disorders and kidney and cardiac damage induced by alloxan.

Conclusion: extract produced nephroprotective, cardioprotective, and haematoprotective effects and might prevent the advancement of diabetic complications such as diabetic nephropathy and cardiovascular diseases in diabetic patients.

Citing Articles

Plant-Based Diets and Phytochemicals in the Management of Diabetes Mellitus and Prevention of Its Complications: A Review.

Ansari P, Khan J, Chowdhury S, Reberio A, Kumar S, Seidel V Nutrients. 2024; 16(21).

PMID: 39519546 PMC: 11547802. DOI: 10.3390/nu16213709.

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