Biochemical Basis of Cyfluthrin and DDT Resistance in (Diptera: Culicidae) in Malarious Area of Iran

Overview

Journal J Arthropod Borne Dis

Publisher Tehran University of Medical Sciences

Date 2018 Dec 26

PMID 30584554

Citations 14

Authors

Mohammad Amin Gorouhi

Mohammad Ali Oshaghi

Hassan Vatandoost

Ahmad Ali Enayati

Ahmad Raeisi

Mohamad Reza Abai

Yaser Salim-Abadie

Ahmad Ali Hanafi-Bojd

Azim Paksa

Fatemeh Nikpoor

Affiliations

Soon will be listed here.

Abstract

Background: is a key urban malaria vector in the Indian subcontinent and Middle East including south and southeast of Iran. Wide application of insecticides resulted in resistance of this species to various insecticides in these regions. This study was conducted to reveal the role of metabolic mechanisms in the development of resistance in to DDT and cyfluthrin.

Methods: Field mosquito specimens were collected from Chabahar Seaport, southeast corner of Iran, in 2015. Insecticide susceptibility and enzyme assays were conducted as recommended by WHO.

Results: Mean enzyme ratios were 3.95 and 3.04 for α- esterases and 2.40 and 1.97 for β- esterases in the DDT and cyfluthrin- resistant populations correspondingly compared with the susceptible strain. The GSTs enzyme mean activity ratios were 5.07 and 2.55 in the DDT and cyfluthrin- resistant populations compared with the susceptible beech strain. The cytochrome p450s enzyme ratios were 1.11 and 1.28 in the DDT and cyfluthrin- resistant populations respectively compared with the susceptible beech strain.

Conclusion: Metabolic mechanisms play a crucial role in the development of DDT and cyfluthrin resistance in , therefore, further evaluation of the mechanisms involved as well as implementation of proper insecticide resistance management strategies are recommended.

Citing Articles

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Insecticide Resistance Status of Malaria Vectors in a Malarious Area, Southeast of Iran.

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