Exploring the Mechanistic Link Between Corticosterone and Insulin-like Growth Factor-1 in a Wild Passerine Bird

Overview

Journal PeerJ

Specialties Biology
Environmental Health
General Medicine

Date 2018 Dec 25

PMID 30581657

Citations 5

Authors

Zsofia Toth

Jenny Q Ouyang

Adam Z Lendvai

Affiliations

Soon will be listed here.

Abstract

Background: Physiological regulators of life history trade-offs need to be responsive to sudden changes of resource availability. When homeostasis is challenged by unpredictable stressors, vertebrates respond through a set of physiological reactions, which can promote organismal survival. Glucocorticoids have been traditionally recognized as one of the main regulators of the physiological stress response, but the role of an evolutionarily more conserved pathway, the hypothalamic-pituitary-somatotropic (HPS) axis producing insulin-like growth factor-1 (IGF-1) has received much less attention. Although IGF-1 is known to affect several life history traits, little is known about its role in the physiological stress response and it has never been studied directly in adult wild animals.

Methods: In this study, we combined field observations with a controlled experiment to investigate how circulating levels of IGF-1 change in response to stress and whether this change is due to concomitant change in glucocorticoids in a free-living songbird, the bearded reedling . We used a standard capture-restraint protocol in field observation, in which we took first and second (stress induced: 15 minutes later) samples. In a follow-up experiment, we used a minimally invasive oral corticosterone manipulation.

Results: We showed that corticosterone levels significantly increased while IGF-1 levels significantly decreased during capture and handling stress. However, change in corticosterone levels were not related to change in IGF-1 levels. We found that experimentally elevated corticosterone levels did not affect IGF-1 levels.

Discussion: Our results are the first to highlight that circulating IGF-1 levels are responsive to stress independently from glucocorticoids and suggest that the HPS axis is an autonomous physiological pathway that may play an important role as regulator of life-history decisions.

Citing Articles

IGF-1 induces sex-specific oxidative damage and mortality in a songbird.

Lendvai A, Toth Z, Mahr K, Penzes J, Vogel-Kindgen S, Gander B Oecologia. 2024; 205(3-4):561-570.

PMID: 39014256 PMC: 11358184. DOI: 10.1007/s00442-024-05587-y.

Sex-specific effects of dietary restriction on physiological variables in Japanese quails.

Reda G, Ndunguru S, Csernus B, Lugata J, Knop R, Szabo C Ecol Evol. 2024; 14(5):e11405.

PMID: 38799393 PMC: 11116846. DOI: 10.1002/ece3.11405.

Dietary restriction reveals sex-specific expression of the mTOR pathway genes in Japanese quails.

Reda G, Ndunguru S, Csernus B, Knop R, Lugata J, Szabo C Sci Rep. 2024; 14(1):8314.

PMID: 38594358 PMC: 11004124. DOI: 10.1038/s41598-024-58487-9.

Heat stress alters muscle protein and amino acid metabolism and accelerates liver gluconeogenesis for energy supply in broilers.

Ma B, Zhang L, Li J, Xing T, Jiang Y, Gao F Poult Sci. 2020; 100(1):215-223.

PMID: 33357684 PMC: 7772709. DOI: 10.1016/j.psj.2020.09.090.

The Relationship between Hormones, Glucose, and Oxidative Damage Is Condition and Stress Dependent in a Free-Living Passerine Bird.

Vagasi C, Toth Z, Penzes J, Pap P, Ouyang J, Lendvai A Physiol Biochem Zool. 2020; 93(6):466-476.

PMID: 33164671 PMC: 7982133. DOI: 10.1086/711957.

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