New 2-(2-phenylethyl)chromone Derivatives from Agarwood and Their Inhibitory Effects on Tumor Cells

Two new chromone derivatives, 7-hydroxy-2-[2-(3'-methoxy-4'-hydroxyphenyl)-ethyl]chromone (), and 6,7-dimethoxy-2-[2-(3'-hydroxyphenyl)-ethyl]chromone () were isolated from the EtOH extract of agarwood of , together with eleven known analogues. Their structures were established by detailed HR-ESIMS, 1D and 2D NMR spectroscopic analysis, as well as comparison with the literature data. Selected the isolates (, , , , ) were tested for their antitumor activities against SMMC-7721, MGC-803 and OV-90 cell lines using the MTT method with cisplatin and paclitaxel as the positive control. All the tested compounds showed weak cytotoxic activities with IC values ranged from 18.82 to 37.95 g/ml.