Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2018 Dec 23

PMID 30577528

Citations 11

Authors

Sanjay Shrestha

Mark Hazelbaker

Amber L Yount

Claire E Walczak

Affiliations

Soon will be listed here.

Abstract

Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation. There are a multitude of cellular factors that regulate the dynamicity of MTs and play critical roles in mitosis. Members of the Kinesin-8 family of motor proteins act as MT-destabilizing factors to control MT length in a spatially and temporally regulated manner. In this review, we focus on recent advances in our understanding of the structure and function of the Kinesin-8 motor domain, and the emerging contributions of the C-terminal tail of Kinesin-8 proteins to regulate motor activity and localization.

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