Self-assembled Membrane Composed of Amyloid-like Proteins for Efficient Size-selective Molecular Separation and Dialysis

Overview

Journal Nat Commun

Specialty Biology

Date 2018 Dec 22

PMID 30575744

Citations 15

Authors

Facui Yang

Fei Tao

Chen Li

Lingxiang Gao

Peng Yang

Affiliations

Soon will be listed here.

Abstract

The design and scalable construction of robust ultrathin protein membranes with tunable separation properties remain a key challenge in chemistry and materials science. Here, we report a macroscopic ultrathin protein membrane with the potential for scaled-up fabrication and excellent separation efficiency. This membrane, which is formed by fast amyloid-like lysozyme aggregation at air/water interface, has a controllable thickness that can be tuned to 30-250 nm and pores with a mean size that can be tailored from 1.8 to 3.2 nm by the protein concentration. This membrane can retain > 3 nm molecules and particles while permitting the transport of small molecules at a rate that is 1~4 orders of magnitude faster than the rate of existing materials. This membrane further exhibits excellent hemodialysis performance, especially for the removal of middle-molecular-weight uremic toxins, which is 5~6 times higher in the clearance per unit area than the typical literature values reported to date.

Citing Articles

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