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The Dose-response Relationships of Dipivalyl Epinephrine in Open-angle Glaucoma

Overview
Journal Albrecht Von Graefes Arch Klin Exp Ophthalmol
Specialty Ophthalmology
Date 1978 Feb 22
PMID 305728
Citations 7
Authors
G K Krieglstein
W LEYDHECKER
Affiliations
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Abstract

The intraocular pressure responses of topically applied dipivalyl epinephrine (DPE: 0.025, 0.1, and 0.25%) were investigated in three series of open angle glaucoma patients in a double blind study. IOP responses were compared intra-individually with the effects of 1% epinephrine hydrochloride. 0.1% DPE gave an IOP reduction similar to that of 1% epinephrine-HCl. The change in IOP was less with 0.025% DPE and statistically significantly greater with 0.25% DPE when compared with the conventional epinephrine preparation. The clinical advantages of the 'pro drug' DPE are pointed out.

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[The effect of timolol and dipivalyl-epinephrine in the treatment of the elevated intraocular pressure (author's transl)].

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A single-blind randomised trial comparing adrenaline 1.0% with dipivalyl epinephrine (propine) 0.1% in the treatment of open-angle glaucoma and ocular hypertension.

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References
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