Effects of Cannabidiol in Males and Females in Two Different Rat Models of Depression

Overview

Journal Physiol Behav

Specialties Physiology
Psychiatry
Psychology
Social Sciences

Date 2018 Dec 21

PMID 30571957

Citations 35

Authors

Liat Shbiro

Danielle Hen-Shoval

Noa Hazut

Kayla Rapps

Shira Dar

Gil Zalsman

Raphael Mechoulam

Aron Weller

Gal Shoval

Affiliations

Soon will be listed here.

Abstract

The current study explores the therapeutic potential of Cannabidiol (CBD), a compound in the Cannabis plant, using both sexes of 2 "depressive-like" genetic models, Wistar Kyoto (WKY) and Flinders Sensitive Line (FSL) rats. Rats ingested CBD (30 mg/kg) orally. In the saccharin preference test, following a previous report of a pro-hedonic effect of CBD in male WKY, we now found similar results in female WKY. CBD also decreased immobility in the forced swim test in males (both strains) and in female WKY. These findings suggest a role for CBD in treating mental disorders with prominent symptoms of helplessness and anhedonia.

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