» Articles » PMID: 30569287

Hinokitiol Offers Neuroprotection Against 6-OHDA-Induced Toxicity in SH-SY5Y Neuroblastoma Cells by Downregulating MRNA Expression of MAO/α-Synuclein/LRRK2/PARK7/PINK1/PTEN Genes

Overview
Journal Neurotox Res
Publisher Springer
Specialty Neurology
Date 2018 Dec 21
PMID 30569287
Citations 7
Authors
Affiliations
Soon will be listed here.
Abstract

Parkinson's disease (PD) remarks its pathology by affecting the patient's movements and postural instability by dopaminergic loss in the substantia nigra of midbrain. The disease is characterized by the accumulation of alpha-synuclein protein followed by dementia symptoms. Moreover, the pathology enhances the production of monoamine oxidases A and B (MAO A and B), leucine-rich repeat kinase 2 (LRRK2), phosphate and tensin homolog (PTEN), PTEN-induced putative kinase 1 (PINK1), and PARK7 (deglycase 1 (DJ-1)). Hinokitiol (HIN), a tropolone-related compound, has widely been reported as an antioxidant, antineuralgic as well as a neuroprotective agent. Hence, in this study, we have examined the effect of hinokitol to act as a neuroprotective agent against 6-OHDA-induced toxicity in SH-SY5Y neuroblastoma cells through downregulation of the mRNA expression of PD pathological proteins like alpha-synuclein, MAO A and B, LRRK2, PTEN, PINK1, and PARK7 (deglycase 1 (DJ-1)). The study revealed that the 6-OHDA-induced elevation in the mRNA expression of the pathology marker proteins was subsequently downregulated by the treatment with HIN and was referenced with the positive control, amantadine (AMA), widely used nowadays as a treatment drug for PD symptoms. Thus, the study suggests that hinokitiol could be a drug of choice against 6-OHDA-induced neurotoxicity in SH-SY5Y neuroblastoma cells.

Citing Articles

Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth.

Zhao H, Zhang M, Zhang J, Sun Z, Zhang W, Dong W Cell Biosci. 2023; 13(1):87.

PMID: 37179385 PMC: 10182687. DOI: 10.1186/s13578-023-01044-0.


Garmultin-A Incites Apoptosis in CB3 Cells Through miR-17-5p by Attenuating Poly (ADP-Ribose) Polymerase-1.

Qiu J, Chen L, Yang J, Varier K, Gajendran B, Yao Y Dose Response. 2022; 20(4):15593258221130681.

PMID: 36246167 PMC: 9558886. DOI: 10.1177/15593258221130681.


Design, Synthesis, and Antileukemic Evaluation of a Novel Mikanolide Derivative Through the Ras/Raf/MEK/ERK Pathway.

Rao Q, Xie K, Varier K, Huang L, Song J, Yang J Front Pharmacol. 2022; 13:809551.

PMID: 35721186 PMC: 9205396. DOI: 10.3389/fphar.2022.809551.


Amantadine Attenuated Hypoxia-Induced Mitochondrial Oxidative Neurotoxicity, Apoptosis, and Inflammation via the Inhibition of TRPM2 and TRPV4 Channels.

Ocal O, Cosar A, Naziroglu M Mol Neurobiol. 2022; 59(6):3703-3720.

PMID: 35366734 DOI: 10.1007/s12035-022-02814-6.


Neuroprotective Effects of Estradiol plus Lithium Chloride via Anti-Apoptosis and Neurogenesis Pathway in and Parkinson's Disease Models.

Lee Y, Feng C, Peng M, Chan T, Chen Y Parkinsons Dis. 2021; 2021:3064892.

PMID: 34721835 PMC: 8556090. DOI: 10.1155/2021/3064892.


References
1.
Soto-Otero R, Mendez-Alvarez E, Hermida-Ameijeiras A, Munoz-Patino A, Labandeira-Garcia J . Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem. 2000; 74(4):1605-12. DOI: 10.1046/j.1471-4159.2000.0741605.x. View

2.
Mitsumoto A, Nakagawa Y . DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin. Free Radic Res. 2002; 35(6):885-93. DOI: 10.1080/10715760100301381. View

3.
Bonifati V, Rizzu P, van Baren M, Schaap O, Breedveld G, Krieger E . Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science. 2002; 299(5604):256-9. DOI: 10.1126/science.1077209. View

4.
Taira T, Saito Y, Niki T, Iguchi-Ariga S, Takahashi K, Ariga H . DJ-1 has a role in antioxidative stress to prevent cell death. EMBO Rep. 2004; 5(2):213-8. PMC: 1298985. DOI: 10.1038/sj.embor.7400074. View

5.
Yang Y, Wu C, Morrow W . The apoptotic and necrotic effects of tomatine adjuvant. Vaccine. 2004; 22(17-18):2316-27. DOI: 10.1016/j.vaccine.2003.10.036. View