A Glucose/O Fuel Cell-based Self-powered Biosensor for Probing a Drug Delivery Model with Self-diagnosis and Self-evaluation

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2018 Dec 21

PMID 30568772

Citations 5

Authors

Linlin Wang

Haohua Shao

Xuanzhao Lu

Wenjing Wang

Jian-Rong Zhang

Rong-Bin Song

Jun-Jie Zhu

Affiliations

Soon will be listed here.

Abstract

Extending the application of self-powered biosensors (SPB) into the drug delivery field is highly desirable. Herein, a robust glucose/O fuel cell-based biosensor is successfully integrated with a targeted drug delivery system to create a self-sustained and highly compact drug delivery model with self-diagnosis and self-evaluation (DDM-SDSE). The glucose/O fuel cell-based biosensor firstly performs its diagnostic function by detecting the biomarkers of cancer. The drug delivery system attached on the anode of the glucose/O fuel cell can be released during the diagnostic operation to guarantee the occurrence of a therapy process. Accompanied by the therapy process, the glucose/O fuel cell-based biosensor can also act as an evaluation component to dynamically monitor the therapy efficacy by analyzing drug-induced apoptotic cells. In addition, the use of an abiotic catalyst largely improves the stability of the glucose/O fuel cell without sacrificing the output performance, further ensuring long-time dynamic evaluation as well as highly sensitive diagnosis and evaluation in this DDM-SDSE. Therefore, the present study not only expands the application of SPBs but also offers a promising "diagnosis-therapy-evaluation" platform to acquire valuable information for clinical cancer therapy.

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