Alpha 2.0
Login Register
» Articles » PMID: 30565863

Neuronatin and Glucose-induced Stress in Pancreatic β-cells

Overview
Journal J Diabetes Investig
Specialty Endocrinology
Date 2018 Dec 20
PMID 30565863
Citations 2
Authors
Shun-Ichiro Asahara
Affiliations
Soon will be listed here.
Abstract

Recently, reports have described the association between neuronatin (Nnat) and endoplasmic reticulum stress, and the promotion of insulin processing by Nnat, the expression of which is greatly induced by glucose stimulation. The roles of Nnat are worthy of note under both physiological and pathological conditions. In this Commentary, I discuss the association between Nnat and glucose-induced stress on the basis of recent knowledge.

Citing Articles

Disruption of perinatal myeloid niches impacts the aging clock of pancreatic β cells.

OSell J, Cirulli V, Pardike S, Aare-Bentsen M, Sdek P, Anderson J iScience. 2024; 27(9):110644.

PMID: 39262794 PMC: 11388196. DOI: 10.1016/j.isci.2024.110644.

Strain-based and sex-biased differences in adrenal and pancreatic gene expression between KK/HlJ and C57BL/6 J mice.

Inglis A, Ubungen R, Farooq S, Mata P, Thiam J, Saleh S BMC Genomics. 2021; 22(1):180.

PMID: 33711921 PMC: 7953684. DOI: 10.1186/s12864-021-07495-4.

References
1.
Talchai C, Xuan S, Lin H, Sussel L, Accili D . Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. Cell. 2012; 150(6):1223-34. PMC: 3445031. DOI: 10.1016/j.cell.2012.07.029. View
2.
Chitnis N, Pytel D, Diehl J . UPR-inducible miRNAs contribute to stressful situations. Trends Biochem Sci. 2013; 38(9):447-52. PMC: 4056666. DOI: 10.1016/j.tibs.2013.06.012. View
3.
Sharma R, ODonnell A, Stamateris R, Ha B, McCloskey K, Reynolds P . Insulin demand regulates β cell number via the unfolded protein response. J Clin Invest. 2015; 125(10):3831-46. PMC: 4607122. DOI: 10.1172/JCI79264. View
4.
Rodriguez-Comas J, Moreno-Asso A, Moreno-Vedia J, Martin M, Castano C, Marza-Florensa A . Stress-Induced MicroRNA-708 Impairs β-Cell Function and Growth. Diabetes. 2017; 66(12):3029-3040. DOI: 10.2337/db16-1569. View
5.
Millership S, da Silva Xavier G, Choudhury A, Bertazzo S, Chabosseau P, Pedroni S . Neuronatin regulates pancreatic β cell insulin content and secretion. J Clin Invest. 2018; 128(8):3369-3381. PMC: 6063487. DOI: 10.1172/JCI120115. View