NKB Signaling in the Posterodorsal Medial Amygdala Stimulates Gonadotropin Release in a Kisspeptin-independent Manner in Female Mice

Overview

Journal Elife

Specialty Biology

Date 2018 Dec 20

PMID 30565563

Citations 12

Authors

Chrysanthi Fergani

Silvia Leon

Stephanie L Padilla

Anne Mj Verstegen

Richard D Palmiter

Victor M Navarro

Affiliations

Soon will be listed here.

Abstract

Editorial Note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).

Citing Articles

NK3R signalling in the posterodorsal medial amygdala is involved in stress-induced suppression of pulsatile LH secretion in female mice.

Ivanova D, Voliotis M, Tsaneva-Atanasova K, OByrne K, Li X J Neuroendocrinol. 2024; 36(5):e13384.

PMID: 38516965 PMC: 11411622. DOI: 10.1111/jne.13384.

Neuroendocrine mechanisms underlying estrogen positive feedback and the LH surge.

Kauffman A Front Neurosci. 2022; 16:953252.

PMID: 35968365 PMC: 9364933. DOI: 10.3389/fnins.2022.953252.

Extrahypothalamic Control of Energy Balance and Its Connection with Reproduction: Roles of the Amygdala.

Pineda R, Torres E, Tena-Sempere M Metabolites. 2021; 11(12).

PMID: 34940594 PMC: 8708157. DOI: 10.3390/metabo11120837.

Running the Female Power Grid Across Lifespan Through Brain Estrogen Signaling.

Ingraham H, Herber C, Krause W Annu Rev Physiol. 2021; 84:59-85.

PMID: 34780257 PMC: 8831472. DOI: 10.1146/annurev-physiol-061121-035914.

Characterization of the Action of Tachykinin Signaling on Pulsatile LH Secretion in Male Mice.

Talbi R, Ferrari K, Choi J, Gerutshang A, McCarthy E, Dischino D Endocrinology. 2021; 162(8).

PMID: 33839770 PMC: 8234505. DOI: 10.1210/endocr/bqab074.

References

Kim J, Semaan S, Clifton D, Steiner R, Dhamija S, Kauffman A . Regulation of Kiss1 expression by sex steroids in the amygdala of the rat and mouse. Endocrinology. 2011; 152(5):2020-30. PMC: 3075940. DOI: 10.1210/en.2010-1498. View

Rajendren G, Moss R . The role of the medial nucleus of amygdala in the mating-induced enhancement of lordosis in female rats: the interaction with luteinizing hormone-releasing hormone neuronal system. Brain Res. 1993; 617(1):81-6. DOI: 10.1016/0006-8993(93)90616-u. View

Pineda R, Plaisier F, Millar R, Ludwig M . Amygdala Kisspeptin Neurons: Putative Mediators of Olfactory Control of the Gonadotropic Axis. Neuroendocrinology. 2016; 104(3):223-238. DOI: 10.1159/000445895. View

Krajewski S, Anderson M, Iles-Shih L, Chen K, Urbanski H, Rance N . Morphologic evidence that neurokinin B modulates gonadotropin-releasing hormone secretion via neurokinin 3 receptors in the rat median eminence. J Comp Neurol. 2005; 489(3):372-86. DOI: 10.1002/cne.20626. View

Lymer J, Sheppard P, Kuun T, Blackman A, Jani N, Mahbub S . Estrogens and their receptors in the medial amygdala rapidly facilitate social recognition in female mice. Psychoneuroendocrinology. 2018; 89:30-38. DOI: 10.1016/j.psyneuen.2017.12.021. View

Ramaswamy S, Seminara S, Plant T . Evidence from the agonadal juvenile male rhesus monkey (Macaca mulatta) for the view that the action of neurokinin B to trigger gonadotropin-releasing hormone release is upstream from the kisspeptin receptor. Neuroendocrinology. 2011; 94(3):237-45. PMC: 3238032. DOI: 10.1159/000329045. View

Fergani C, Navarro V . Expanding the Role of Tachykinins in the Neuroendocrine Control of Reproduction. Reproduction. 2016; 153(1):R1-R14. DOI: 10.1530/REP-16-0378. View

Roa J, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M . New frontiers in kisspeptin/GPR54 physiology as fundamental gatekeepers of reproductive function. Front Neuroendocrinol. 2007; 29(1):48-69. DOI: 10.1016/j.yfrne.2007.07.002. View

Idris A . Ovariectomy/orchidectomy in rodents. Methods Mol Biol. 2011; 816:545-51. DOI: 10.1007/978-1-61779-415-5_34. View

10.

Andero R, Daniel S, Guo J, Bruner R, Seth S, Marvar P . Amygdala-Dependent Molecular Mechanisms of the Tac2 Pathway in Fear Learning. Neuropsychopharmacology. 2016; 41(11):2714-22. PMC: 5026739. DOI: 10.1038/npp.2016.77. View

11.

Comninos A, Anastasovska J, Sahuri-Arisoylu M, Li X, Li S, Hu M . Kisspeptin signaling in the amygdala modulates reproductive hormone secretion. Brain Struct Funct. 2015; 221(4):2035-47. PMC: 4853463. DOI: 10.1007/s00429-015-1024-9. View

12.

Gaskins G, Glanowska K, Moenter S . Activation of neurokinin 3 receptors stimulates GnRH release in a location-dependent but kisspeptin-independent manner in adult mice. Endocrinology. 2013; 154(11):3984-9. PMC: 3800761. DOI: 10.1210/en.2013-1479. View

13.

Mileusnic D, Lee J, Magnuson D, Hejna M, Krause J, Lorens J . Neurokinin-3 receptor distribution in rat and human brain: an immunohistochemical study. Neuroscience. 1999; 89(4):1269-90. DOI: 10.1016/s0306-4522(98)00349-2. View

14.

Billings H, Connors J, Altman S, Hileman S, Holaskova I, Lehman M . Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep. Endocrinology. 2010; 151(8):3836-46. PMC: 2940514. DOI: 10.1210/en.2010-0174. View

15.

Seminara S, Messager S, Chatzidaki E, Thresher R, Acierno Jr J, Shagoury J . The GPR54 gene as a regulator of puberty. N Engl J Med. 2003; 349(17):1614-27. DOI: 10.1056/NEJMoa035322. View

16.

de Croft S, Boehm U, Herbison A . Neurokinin B activates arcuate kisspeptin neurons through multiple tachykinin receptors in the male mouse. Endocrinology. 2013; 154(8):2750-60. DOI: 10.1210/en.2013-1231. View

17.

Glowinski J, Kemel M, Desban M, Gauchy C, Lavielle S, Chassaing G . Distinct presynaptic control of dopamine release in striosomal- and matrix-enriched areas of the rat striatum by selective agonists of NK1, NK2 and NK3 tachykinin receptors. Regul Pept. 1993; 46(1-2):124-8. DOI: 10.1016/0167-0115(93)90022-z. View

18.

Navarro V, Castellano J, McConkey S, Pineda R, Ruiz-Pino F, Pinilla L . Interactions between kisspeptin and neurokinin B in the control of GnRH secretion in the female rat. Am J Physiol Endocrinol Metab. 2010; 300(1):E202-10. PMC: 3774070. DOI: 10.1152/ajpendo.00517.2010. View

19.

Ben-Shaanan T, Azulay-Debby H, Dubovik T, Starosvetsky E, Korin B, Schiller M . Activation of the reward system boosts innate and adaptive immunity. Nat Med. 2016; 22(8):940-4. DOI: 10.1038/nm.4133. View

20.

Navarro V, Gottsch M, Chavkin C, Okamura H, Clifton D, Steiner R . Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci. 2009; 29(38):11859-66. PMC: 2793332. DOI: 10.1523/JNEUROSCI.1569-09.2009. View