Green Pharmacy - a Narrative Review

Overview

Journal Clujul Med

Specialty General Medicine

Date 2018 Dec 20

PMID 30564014

Citations 4

Authors

Alexandra Toma

Ofelia Crisan

Affiliations

Soon will be listed here.

Abstract

Introduction: Active pharmaceutical ingredients are present in various sections of the environment, because of both the human and veterinary use of medicinal products. Ways of minimizing the risk of environmental contamination should be observed during all pharmaceutical activities (research, manufacturing, prescribing, dispensing and disposal of medicinal products).

Methods: For the present study we searched specific literature on this subject, using the main international databases (Thomson Reuters - Web of Science, SCOPUS and Science Direct).

Results: This narrative review focuses on the main aspects concerning environmental contamination with medicinal products. Consequently, the present study is structured on four different topics: environmental research on medicinal products, minimizing environmental contamination, waste disposal management and towards a greener community pharmacy.

Conclusion: Waste management activities are important for reducing the presence of active pharmaceutical ingredients in the environment. Pharmacists should inform patients on proper pharmaceutical waste disposal and organize collection programs for unused and expired medicines, in order to develop a greener pharmacy for the future.

Citing Articles

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Veress S, Kerekes-Mathe B, Szekely M Med Pharm Rep. 2023; 96(2):199-205.

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Impact of Social Forces and Environmental Factors on Healthcare and Pharmacy Education: The Report of the 2021-2022 AACP Argus Commission.

DiPiro J, Allen D, Lin A, Scott S, Sorensen T, Maine L Am J Pharm Educ. 2023; 87(1):ajpe9452.

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Assessing the scale of adoption of sustainability practices by community pharmacies in Spain in the time of COVID-19.

Derqui B, Filimonau V, Matute J Sustain Prod Consum. 2022; 27:1626-1636.

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The Effect of Quality Indicators on Beliefs about Medicines Reuse: An Experimental Study.

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References

Crain S, Shen K . Acute thermal hyperalgesia elicited by low-dose morphine in normal mice is blocked by ultra-low-dose naltrexone, unmasking potent opioid analgesia. Brain Res. 2001; 888(1):75-82. DOI: 10.1016/s0006-8993(00)03010-9. View

Heberer T . Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol Lett. 2002; 131(1-2):5-17. DOI: 10.1016/s0378-4274(02)00041-3. View

Daughton C . Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. I. Rationale for and avenues toward a green pharmacy. Environ Health Perspect. 2003; 111(5):757-74. PMC: 1241487. DOI: 10.1289/ehp.5947. View

Daughton C . Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. II. Drug disposal, waste reduction, and future directions. Environ Health Perspect. 2003; 111(5):775-85. PMC: 1241488. DOI: 10.1289/ehp.5948. View

Jones O, Lester J, Voulvoulis N . Pharmaceuticals: a threat to drinking water?. Trends Biotechnol. 2005; 23(4):163-7. DOI: 10.1016/j.tibtech.2005.02.001. View

Zuccato E, Castiglioni S, Fanelli R . Identification of the pharmaceuticals for human use contaminating the Italian aquatic environment. J Hazard Mater. 2005; 122(3):205-9. DOI: 10.1016/j.jhazmat.2005.03.001. View

Isidori M, Lavorgna M, Nardelli A, Parrella A, Previtera L, Rubino M . Ecotoxicity of naproxen and its phototransformation products. Sci Total Environ. 2005; 348(1-3):93-101. DOI: 10.1016/j.scitotenv.2004.12.068. View

Fent K, Weston A, Caminada D . Ecotoxicology of human pharmaceuticals. Aquat Toxicol. 2005; 76(2):122-59. DOI: 10.1016/j.aquatox.2005.09.009. View

Brown K, Kulis J, Thomson B, Chapman T, Mawhinney D . Occurrence of antibiotics in hospital, residential, and dairy effluent, municipal wastewater, and the Rio Grande in New Mexico. Sci Total Environ. 2005; 366(2-3):772-83. DOI: 10.1016/j.scitotenv.2005.10.007. View

10.

Lissemore L, Hao C, Yang P, Sibley P, Mabury S, Solomon K . An exposure assessment for selected pharmaceuticals within a watershed in Southern Ontario. Chemosphere. 2006; 64(5):717-29. DOI: 10.1016/j.chemosphere.2005.11.015. View

11.

Moldovan Z, Schmutzer G, Tusa F, Calin R, Alder A . An overview of pharmaceuticals and personal care products contamination along the river Somes watershed, Romania. J Environ Monit. 2007; 9(9):986-93. DOI: 10.1039/b704076h. View

12.

Glassmeyer S, Hinchey E, Boehme S, Daughton C, Ruhoy I, Conerly O . Disposal practices for unwanted residential medications in the United States. Environ Int. 2008; 35(3):566-72. DOI: 10.1016/j.envint.2008.10.007. View

13.

Lubick N . Opening the "green pharmacy". Environ Sci Technol. 2009; 42(23):8620-1. DOI: 10.1021/es802555w. View

14.

Kummerer K . The presence of pharmaceuticals in the environment due to human use--present knowledge and future challenges. J Environ Manage. 2009; 90(8):2354-66. DOI: 10.1016/j.jenvman.2009.01.023. View

15.

Kasprzyk-Hordern B, Dinsdale R, Guwy A . Illicit drugs and pharmaceuticals in the environment--forensic applications of environmental data, Part 2: Pharmaceuticals as chemical markers of faecal water contamination. Environ Pollut. 2009; 157(6):1778-86. DOI: 10.1016/j.envpol.2009.02.019. View

16.

Kasprzyk-Hordern B, Dinsdale R, Guwy A . Illicit drugs and pharmaceuticals in the environment--forensic applications of environmental data. Part 1: Estimation of the usage of drugs in local communities. Environ Pollut. 2009; 157(6):1773-7. DOI: 10.1016/j.envpol.2009.03.017. View

17.

Calisto V, Esteves V . Psychiatric pharmaceuticals in the environment. Chemosphere. 2009; 77(10):1257-74. DOI: 10.1016/j.chemosphere.2009.09.021. View

18.

Van De Steene J, Stove C, Lambert W . A field study on 8 pharmaceuticals and 1 pesticide in Belgium: removal rates in waste water treatment plants and occurrence in surface water. Sci Total Environ. 2010; 408(16):3448-53. DOI: 10.1016/j.scitotenv.2010.04.037. View

19.

Zhang Y, Geissen S . Prediction of carbamazepine in sewage treatment plant effluents and its implications for control strategies of pharmaceutical aquatic contamination. Chemosphere. 2010; 80(11):1345-52. DOI: 10.1016/j.chemosphere.2010.06.030. View

20.

Gray-Winnett M, Davis C, Yokley S, Franks A . From dispensing to disposal: the role of student pharmacists in medication disposal and the implementation of a take-back program. J Am Pharm Assoc (2003). 2010; 50(5):613-8. DOI: 10.1331/JAPhA.2010.09197. View