Tuberculosis-Human Immunodeficiency Virus (HIV) Co-infection in Ethiopia: a Systematic Review and Meta-analysis

Overview

Journal BMC Infect Dis

Publisher Biomed Central

Specialty Infectious Diseases

Date 2018 Dec 20

PMID 30563476

Citations 19

Authors

Mebrahtu Teweldemedhin

Negasi Asres

Hailay Gebreyesus

Solomon Weldegebreal Asgedom

Affiliations

Soon will be listed here.

Abstract

Background: Human Immunodeficiency Virus (HIV) and Tuberculosis (TB) are the double burden diseases of the world. The African continent takes a great share of TB-HIV cases worldwide. This study was aimed to determine the prevalence of TB-HIV co-infection in Ethiopia, using a meta-analysis based on a systematic review of published articles.

Methods: An electronic search was conducted in databases including PubMed, HINARI, EMBASE, Cochrane library and Google Scholar to extract the articles. Articles published between 1995 and November 2017 had been searched for using different keywords. The analysis was performed using MetaXL software and R statistical software (version 3.2.3).

Result: Our searches returned a total of (n = 26,746) records from 30 articles of which 21 were cross-sectional, 7 were retrospectives and 2 were prospective studies. The range of prevalence of TB-HIV co-infection was found to be from 6 to 52.1% with random effects pooled prevalence of 22% (95% CI 19-24%) and with substantial heterogeneity chi-square (X) = 746.0, p < 0.001, (I = 95.84%).

Conclusion: Our analysis indicated that the prevalence of TB-HIV co-infection is high in Ethiopia with substantial regional variation. An integrated, facility-based and community-based effort towards the prevention, early detection and management of cases should be further strengthened throughout the country to mitigate the double burden disease.

Citing Articles

Multidrug Resistance Tuberculosis in the Context of Co-Infection in Ethiopia: A Systematic Review and Meta-Analysis.

Hailu B, Demessie Y, Gessese A, Dagnaw G, Dejene H J Epidemiol Glob Health. 2025; 15(1):19.

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Prevalence and determinants of TB/HIV coinfection: the double tragedy of infectious disease burden - a 5-year retrospective study in a tertiary health facility in Enugu State, Nigeria.

Nwoga H, Igweagu C, Umeh G BMJ Open. 2024; 14(11):e088287.

PMID: 39613440 PMC: 11605814. DOI: 10.1136/bmjopen-2024-088287.

Mortality and associated factors among patients with TB-HIV co-infection in Ethiopia: a systematic review and meta-analysis.

Moges S, Lajore B BMC Infect Dis. 2024; 24(1):773.

PMID: 39095740 PMC: 11295522. DOI: 10.1186/s12879-024-09683-5.

Treatment outcomes of tuberculosis cases by HIV status in Haramaya General Hospital, Ethiopia: A retrospective cross-sectional study.

Ahmed A, Weldegebreal F, Tebeje F, Dessie Y Medicine (Baltimore). 2024; 103(18):e38034.

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Inhibition of caspase pathways limits CD4 T cell loss and restores host anti-retroviral function in HIV-1 infected humanized mice with augmented lymphoid tissue.

Holloway A, Saito T, Naqvi K, Huante M, Fan X, Lisinicchia J Retrovirology. 2024; 21(1):8.

PMID: 38693565 PMC: 11064318. DOI: 10.1186/s12977-024-00641-2.

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