Antiviral and Antioxidant Properties of Echinochrome A

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2018 Dec 19

PMID 30558297

Citations 40

Authors

Sergey A Fedoreyev

Natalia V Krylova

Natalia P Mishchenko

Elena A Vasileva

Evgeny A Pislyagin

Olga V Iunikhina

Vyacheslav F Lavrov

Oksana A Svitich

Linna K Ebralidze

Galina N Leonova

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to examine the in vitro antioxidant and antiviral activities of echinochrome A and echinochrome-based antioxidant composition against tick-borne encephalitis virus (TBEV) and herpes simplex virus type 1 (HSV-1). The antioxidant composition, which is a mixture of echinochrome A, ascorbic acid, and α-tocopherol (5:5:1), showed higher antioxidant and antiviral effects than echinochrome A. We suppose that echinochrome A and its composition can both directly affect virus particles and indirectly enhance antioxidant defense mechanisms in the hosting cell. The obtained results allow considering the echinochrome A and the composition of antioxidants on its basis as the promising agents with the both antioxidant and antiviral activities.

Citing Articles

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Interaction of Liposomes Containing the Carrageenan/Echinochrome Complex with Human HaCaT Keratinocytes In Vitro.

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Hematopoietic effect of echinochrome on phenylhydrazine-induced hemolytic anemia in rats.

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