Suppression of Type I Interferon Signaling by NS5

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2018 Dec 19

PMID 30558110

Citations 29

Authors

Stephanie Thurmond

Boxiao Wang

Jikui Song

Rong Hai

Affiliations

Soon will be listed here.

Abstract

Type I interferon (IFN-I) is the first line of mammalian host defense against viral infection. To counteract this, the flaviviruses, like other viruses, have encoded a variety of antagonists, and use a multi-layered molecular defense strategy to establish their infections. Among the most potent antagonists is non-structural protein 5 (NS5), which has been shown for all disease-causing flaviviruses to target different steps and players of the type I IFN signaling pathway. Here, we summarize the type I IFN antagonist mechanisms used by flaviviruses with a focus on the role of NS5 in regulating one key regulator of type I IFN, signal transducer and activator of transcription 2 (STAT2).

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