A Study on the Association Between Mutation and HCV Infection in Iranian Patients

Overview

Journal Avicenna J Med Biotechnol

Specialty Biomedical Engineering

Date 2018 Dec 18

PMID 30555661

Citations 2

Authors

Farahnaz Bineshian

Asieh Hosseini

Zohre Sharifi

Afsaneh Aghaie

Affiliations

Soon will be listed here.

Abstract

Background: Mutations in the coding region of the Chemokine Receptor 5 (5) genes reduce or eliminate expression in immune cells and progression of HCV infection. This study aimed to investigate the role of this mutation in HCV infection in Iranian patients in comparison with healthy individuals.

Methods: 100 HCV infected patients and 100 healthy individuals were randomly selected. The genotypes were determined using specific primers and PCR method.

Results: The agarose gel electrophoresis showed a189- fragment from wild type for both alleles of gene. The allele was not found in any HCV infected and healthy subjects.

Conclusion: The mutation in gene was not detected in any of the two groups; therefore, the role of gene expression in immune cells and progression of HCV infection needs to be studied in larger samples in our country.

Citing Articles

Beyond HIV infection: Neglected and varied impacts of CCR5 and CCR5Δ32 on viral diseases.

Ellwanger J, Kulmann-Leal B, Kaminski V, Rodrigues A, Bragatte M, Chies J Virus Res. 2020; 286:198040.

PMID: 32479976 PMC: 7260533. DOI: 10.1016/j.virusres.2020.198040.

Prevalence of CCR5delta32 in Northeastern Iran.

Tajbakhsh A, Fazeli M, Rezaee M, Ghasemi F, Momen Heravi M, Gholoobi A BMC Med Genet. 2019; 20(1):184.

PMID: 31730458 PMC: 6858674. DOI: 10.1186/s12881-019-0913-9.

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