and Thyroid: A Pleiotropic Candidate Gene for Congenital Hypothyroidism

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2018 Dec 18

PMID 30555422

Citations 8

Authors

Giuditta Rurale

Luca Persani

Federica Marelli

Affiliations

Soon will be listed here.

Abstract

Variations in the transcription factor Gli-similar 3 () gene have been associated to variable congenital endocrine defects, including both morphogenetic and functional thyroid alterations. Evidence from Glis3 knockout mice indicates a relevant role for in thyroid hormone biosynthesis and postnatal thyroid gland growth, with a mechanism of action downstream of the TSH/TSHR interaction. However, the pathophysiological role of this transcription factor during the embryonic thyroid development remains unexplored. In this manuscript, we will provide an overview of the current knowledge on function during development. As a perspective, we will present preliminary evidence in the zebrafish model in support of a potential role for this pleiotropic transcription factor in the early stages of thyroid gland development.

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References

Wendl T, Lun K, Mione M, Favor J, Brand M, Wilson S . Pax2.1 is required for the development of thyroid follicles in zebrafish. Development. 2002; 129(15):3751-60. DOI: 10.1242/dev.129.15.3751. View

Kim Y, Nakanishi G, Lewandoski M, Jetten A . GLIS3, a novel member of the GLIS subfamily of Krüppel-like zinc finger proteins with repressor and activation functions. Nucleic Acids Res. 2003; 31(19):5513-25. PMC: 206473. DOI: 10.1093/nar/gkg776. View

Senee V, Chelala C, Duchatelet S, Feng D, Blanc H, Cossec J . Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism. Nat Genet. 2006; 38(6):682-7. DOI: 10.1038/ng1802. View

Lieschke G, Currie P . Animal models of human disease: zebrafish swim into view. Nat Rev Genet. 2007; 8(5):353-67. DOI: 10.1038/nrg2091. View

Thisse C, Thisse B . High-resolution in situ hybridization to whole-mount zebrafish embryos. Nat Protoc. 2008; 3(1):59-69. DOI: 10.1038/nprot.2007.514. View

Yang Y, Chang B, Samson S, Li M, Chan L . The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription. Nucleic Acids Res. 2009; 37(8):2529-38. PMC: 2677877. DOI: 10.1093/nar/gkp122. View

Kang H, Beak J, Kim Y, Herbert R, Jetten A . Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease. Mol Cell Biol. 2009; 29(10):2556-69. PMC: 2682055. DOI: 10.1128/MCB.01620-08. View

Watanabe N, Hiramatsu K, Miyamoto R, Yasuda K, Suzuki N, Oshima N . A murine model of neonatal diabetes mellitus in Glis3-deficient mice. FEBS Lett. 2009; 583(12):2108-13. DOI: 10.1016/j.febslet.2009.05.039. View

Porazzi P, Calebiro D, Benato F, Tiso N, Persani L . Thyroid gland development and function in the zebrafish model. Mol Cell Endocrinol. 2009; 312(1-2):14-23. DOI: 10.1016/j.mce.2009.05.011. View

10.

Kang H, Kim Y, ZeRuth G, Beak J, Gerrish K, Kilic G . Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression. Mol Cell Biol. 2009; 29(24):6366-79. PMC: 2786880. DOI: 10.1128/MCB.01259-09. View

11.

Dimitri P, Warner J, Minton J, Patch A, Ellard S, Hattersley A . Novel GLIS3 mutations demonstrate an extended multisystem phenotype. Eur J Endocrinol. 2010; 164(3):437-43. DOI: 10.1530/EJE-10-0893. View

12.

ZeRuth G, Yang X, Jetten A . Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused. J Biol Chem. 2011; 286(25):22077-89. PMC: 3121352. DOI: 10.1074/jbc.M111.224964. View

13.

Opitz R, Maquet E, Zoenen M, Dadhich R, Costagliola S . TSH receptor function is required for normal thyroid differentiation in zebrafish. Mol Endocrinol. 2011; 25(9):1579-99. PMC: 5417235. DOI: 10.1210/me.2011-0046. View

14.

Lichti-Kaiser K, ZeRuth G, Kang H, Vasanth S, Jetten A . Gli-similar proteins: their mechanisms of action, physiological functions, and roles in disease. Vitam Horm. 2012; 88:141-71. PMC: 3799816. DOI: 10.1016/B978-0-12-394622-5.00007-9. View

15.

Heuer H, Visser T . The pathophysiological consequences of thyroid hormone transporter deficiencies: Insights from mouse models. Biochim Biophys Acta. 2012; 1830(7):3974-8. DOI: 10.1016/j.bbagen.2012.04.009. View

16.

Porazzi P, Marelli F, Benato F, de Filippis T, Calebiro D, Argenton F . Disruptions of global and JAGGED1-mediated notch signaling affect thyroid morphogenesis in the zebrafish. Endocrinology. 2012; 153(11):5645-58. DOI: 10.1210/en.2011-1888. View

17.

ZeRuth G, Takeda Y, Jetten A . The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription. Mol Endocrinol. 2013; 27(10):1692-705. PMC: 3787130. DOI: 10.1210/me.2013-1117. View

18.

Lichti-Kaiser K, ZeRuth G, Jetten A . TRANSCRIPTION FACTOR GLI-SIMILAR 3 (GLIS3): IMPLICATIONS FOR THE DEVELOPMENT OF CONGENITAL HYPOTHYROIDISM. J Endocrinol Diabetes Obes. 2014; 2(2):1024. PMC: 4131692. View

19.

ZeRuth G, Williams J, Cole Y, Jetten A . HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity. PLoS One. 2015; 10(7):e0131303. PMC: 4493090. DOI: 10.1371/journal.pone.0131303. View

20.

Zhang J, Yuan S, Vasilyev A, Arnaout M . The transcriptional coactivator Taz regulates proximodistal patterning of the pronephric tubule in zebrafish. Mech Dev. 2015; 138 Pt 3:328-35. PMC: 4679655. DOI: 10.1016/j.mod.2015.08.001. View