An ELISA Test for Detecting Chloroquine in Urine

Overview

Journal Trans R Soc Trop Med Hyg

Publisher Oxford University Press

Specialties Public Health
Tropical Medicine

Date 1988 Jan 1

PMID 3055457

Citations 5

Authors

F C Shenton

M Bots

A Menon

T A Eggelte

M de Wit

B M Greenwood

Affiliations

Soon will be listed here.

Abstract

Two ELISA tests for detecting chloroquine in urine have been developed using polyclonal and monoclonal antibodies which react with the 7-chloro-4-amino-quinoline part of the chloroquine molecule and thus recognize chloroquine, its metabolites, and amodiaquine. The ELISAs were sensitive and specific and did not cross-react with other commonly used antimalarials. In a field trial the chloroquine ELISA performed better than the Dill Glazko or Haskins colorimetric tests. A small proportion of urines gave an apparently false positive reaction when tested at a dilution of 1:10, but not when tested at higher dilution.

Citing Articles

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