G Protein-coupled Receptors in Arthropod Vectors: Omics and Pharmacological Approaches to Elucidate Ligand-receptor Interactions and Novel Organismal Functions

Overview

Journal Curr Opin Insect Sci

Publisher Elsevier

Specialty Biology

Date 2018 Dec 16

PMID 30551818

Citations 12

Authors

Patricia V Pietrantonio

Caixing Xiong

Ronald James Nachman

Yang Shen

Affiliations

Soon will be listed here.

Abstract

Regulation of many physiological processes in animals, certainly those controlled by neuropeptide hormones, involves G protein-coupled receptors (GPCRs). Our work focusing on endocrine regulation of diuresis and water balance in mosquitoes and ticks started in 1997 with the kinin receptor, at the dawn of the omics era. After the genomic revolution, we began work on the endocrinology of reproduction in the red imported fire ant. We will use the template of this comparative work to summarize key points about GPCRs and signaling, and emphasize the most recent developments in the pharmacology of arthropod neuropeptide GPCRs. We will discuss omics' contributions to the advancement of this field, and its influence on peptidomimetic design while emphasizing work on blood feeding arthropods.

Citing Articles

A fluorescently-tagged tick kinin neuropeptide triggers peristalsis and labels tick midgut muscles.

Hernandez J, Xiong C, Pietrantonio P Sci Rep. 2024; 14(1):10863.

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Hearing of malaria mosquitoes is modulated by a beta-adrenergic-like octopamine receptor which serves as insecticide target.

Georgiades M, Alampounti A, Somers J, Su M, Ellis D, Bagi J Nat Commun. 2023; 14(1):4338.

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Putative target sites in synganglion for novel ixodid tick control strategies.

Waldman J, Klafke G, Tirloni L, Logullo C, da Silva Vaz Jr I Ticks Tick Borne Dis. 2023; 14(3):102123.

PMID: 36716581 PMC: 10033424. DOI: 10.1016/j.ttbdis.2023.102123.

Periviscerokinin (Cap; CAPA) receptor silencing in females of Rhipicephalus microplus reduces survival, weight and reproductive output.

Wulff J, Temeyer K, Tidwell J, Schlechte K, Lohmeyer K, Pietrantonio P Parasit Vectors. 2022; 15(1):359.

PMID: 36203198 PMC: 9535995. DOI: 10.1186/s13071-022-05457-7.

Pyrokinin receptor silencing in females of the southern cattle tick Rhipicephalus (Boophilus) microplus is associated with a reproductive fitness cost.

Wulff J, Temeyer K, Tidwell J, Schlechte K, Xiong C, Lohmeyer K Parasit Vectors. 2022; 15(1):252.

PMID: 35818078 PMC: 9272880. DOI: 10.1186/s13071-022-05349-w.

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