MicroRNA Expression is Associated with Sepsis Disorders in Critically Ill Polytrauma Patients

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2018 Dec 16

PMID 30551680

Citations 13

Authors

Alexandru Florin Rogobete

Dorel Sandesc

Ovidiu Horea Bedreag

Marius Papurica

Sonia Elena Popovici

Tiberiu Bratu

Calin Marius Popoiu

Razvan Nitu

Tiberiu Dragomir

Hazzaa I M AAbed

Mihaela Viviana Ivan

Affiliations

Soon will be listed here.

Abstract

A critically ill polytrauma patient is one of the most complex cases to be admitted to the intensive care unit, due to both the primary traumatic complications and the secondary post-traumatic interactions. From a molecular, genetic, and epigenetic point of view, numerous biochemical interactions are responsible for the deterioration of the clinical status of a patient, and increased mortality rates. From a molecular viewpoint, microRNAs are one of the most complex macromolecular systems due to the numerous modular reactions and interactions that they are involved in. Regarding the expression and activity of microRNAs in sepsis, their usefulness has reached new levels of significance. MicroRNAs can be used both as an early biomarker for sepsis, and as a therapeutic target because of their ability to block the complex reactions involved in the initiation, maintenance, and augmentation of the clinical status.

Citing Articles

Dual Roles of Plasma miRNAs in Myocardial Injuries After Polytrauma: miR-122-5p and miR-885-5p Reflect Inflammatory Response, While miR-499a-5p and miR-194-5p Contribute to Cardiomyocyte Damage.

Han J, Leppik L, Sztulman L, de Rosa R, Pfeiffer V, Busse L Cells. 2025; 14(4).

PMID: 39996771 PMC: 11854772. DOI: 10.3390/cells14040300.

Review of the Predictive Value of Biomarkers in Sepsis Mortality.

Zhang N, Liu Y, Yang C, Li X Emerg Med Int. 2024; 2024:2715606.

PMID: 38938850 PMC: 11208822. DOI: 10.1155/2024/2715606.

miR-126-5p expression in the plasma of patients with sepsis-induced acute lung injury and its correlation with inflammation and immune function.

Mao X, Wu Y, Xu W Clin Respir J. 2023; 17(7):629-637.

PMID: 37248197 PMC: 10363794. DOI: 10.1111/crj.13646.

Multimodal Diagnostic Methods of Sepsis in Critically Ill Patients.

Rogobete A, Sandesc D Diagnostics (Basel). 2022; 12(8).

PMID: 36010300 PMC: 9406491. DOI: 10.3390/diagnostics12081950.

MicroRNA-155-5p modulates the progression of acute respiratory distress syndrome by targeting interleukin receptors.

Huang Z, Huang H, Shen M, Li C, Liu C, Zhu H Bioengineered. 2022; 13(5):11732-11741.

PMID: 35506298 PMC: 9276023. DOI: 10.1080/21655979.2022.2071020.

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